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dc.creatorQuintero Vélez, Juan Carlos
dc.creatorAguirre Acevedo, Daniel Camilo
dc.creatorRodas González, Juan David
dc.creatorArboleda, Margarita
dc.creatorTroyo Rodríguez, Adriana
dc.creatorVega Aguilar, Francisco
dc.creatorOsorio Quintero, Lisardo
dc.creatorRojas Arbeláez, Carlos
dc.date.accessioned2019-02-18T16:43:09Z
dc.date.available2019-02-18T16:43:09Z
dc.date.issued2018-10-31
dc.identifier.citationhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006911es_ES
dc.identifier.issn1935-2735
dc.identifier.urihttps://hdl.handle.net/10669/76582
dc.description.abstractIntroduction Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although cross-sectional studies are essential to detect people exposed to rickettsiae, they are not suited to demonstrate the recent circulation of this pathogen in areas at risk of transmission. Objective To characterize the epidemiology of incident cases of Spotted fever group (SFG) rickettsial infection in humans and equines from rural areas of Uraba´ region in Colombia where outbreaks of rickettsiae previously occurred. Materials and methods A prospective study was conducted in the Alto de Mulatos and Las Changas in the Uraba´ region. Serum samples and socio-ecological information were collected from 597 people enrolled in 2015, and a second sample was collected from 273 people a year later. Indirect immune-fluorescence assays for detection of IgG antibody against rickettsiae were done using slides with Rickettsia rickettsii antigens. A titer 128 was considered positive. Incident cases were defined as (i) serological conversion of IgG titers from seronegative to seropositive or (ii) at least a four-fold increase in IgG end point titers in the second sample. Results The cumulative incidence of rickettsial infection was 6.23% (95%CI 3.67–9.78) in humans and 32.31% (21/65) of incident cases in equines. Incident cases were mostly females (82.35%), the median age of cases was 41.02 years (IQR 18.62–54.1), and 29.41% reported tick bites during the study period. Results from multivariate analysis showed that removal of ticks after working outdoors is a protective factor for rickettsial infection (RR 0.26, 95%CI 0.08–0.84) and that a higher incidence of infection occurred in people who reported fever in the last year (RR 4.26, 95%CI 1.15–9.31). Conclusions These results showed recent circulation of SFG rickettsiae in areas where previous lethal outbreaks have been reported, supporting the implementation of preventive measures to halt rickettsial transmission in the studied communities.es_ES
dc.language.isoen_USes_ES
dc.relation.ispartof
dc.sourcePLOS Neglected Tropical Diseases, vol.12(10), art. e0006911es_ES
dc.subjectEquineses_ES
dc.subjectRickettsia rickettsiies_ES
dc.subjectTickses_ES
dc.subjectColombiaes_ES
dc.subjectFeverses_ES
dc.subjectUrban areases_ES
dc.titleEpidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombiaes_ES
dc.typeartículo científicoes_ES
dc.date.updated2018-12-19T20:57:08Z
dc.identifier.doi10.1371/journal.pntd.0006911
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES


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