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dc.creatorCordero García, Eugenia
dc.creatorRamos Esquivel, Allan Eduardo
dc.creatorAlpízar Alpízar, Warner
dc.date.accessioned2019-08-27T21:40:08Z
dc.date.available2019-08-27T21:40:08Z
dc.date.issued2017
dc.identifier.citationhttp://jgo.amegroups.com/article/view/17112
dc.identifier.issn2219-679X
dc.identifier.issn2078-6891
dc.identifier.urihttps://hdl.handle.net/10669/78920
dc.description.abstractBackground: Gastric cancer is one of the major causes of cancer-related deaths in several Latin-American countries, including Costa Rica. However, determinants of poor outcomes are fairly unknown for patients from this region. The aim of this study was to determine prognostic variables of overall survival (OS) in a cohort of Hispanic patients after curative-intent surgery for gastric cancer. Methods: We retrospectively evaluated the clinical records of 236 consecutive patients who underwent surgery for advanced gastric cancer at four major hospitals in Costa Rica. Univariate and multivariate Cox proportional models were used to assess the influence of age, sex, clinical stage, adjuvant therapy, type of dissection (D1 vs. D2), extent of gastrectomy (partial vs. total), margin status (R0 vs. R1/2), tumour differentiation, and tumour location on OS. Results: After a median follow-up of 46.5 months, median OS was 47.6 months [95% confidence interval (CI): 34.7–60.4]. There was no survival benefit of adjuvant chemotherapy [hazard ratio (HR): 1.18; 95% CI: 0.70–2.00; P=0.53] or postoperative chemoradiotherapy (CRT) (HR: 1.04; 95% CI: 0.71–1.52; P=0.85) compared to surgery alone. After adjustment for potential confounders, the R0 status was associated with better OS (HR: 0.51; 95% CI: 0.28–0.92; P=0.03). Similarly, clinical stage (III vs. I) (HR: 2.26; 95% CI: 1.39–4.29; P=0.001), poor differentiated (HR: 1.72; 95% CI: 1.22–2.76; P=0.03) and undifferentiated tumours (HR: 2.37; 95% CI: 1.39–4.23; P=0.001) were associated with worse outcomes. Conclusions: The surgical margin status, clinical stage, and tumour differentiation were predictor variables for OS in this cohort of gastric cancer patients.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[817-B2-371]/UCR/Costa Rica
dc.language.isoen_USes_ES
dc.sourceJournal of Gastrointestinal Oncology, vol. 9(1), pp.64-72es_ES
dc.subjectGastrectomyes_ES
dc.subjectLatin Americaes_ES
dc.subjectPrognosises_ES
dc.subjectSurvivales_ES
dc.subjectStomach neoplasmes_ES
dc.titlePredictors of overall survival after surgery in gastric cancer patients from a Latin-American countryes_ES
dc.typeartículo científico
dc.identifier.doi10.21037/jgo.2017.10.07
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Farmaciaes_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES
dc.identifier.codproyecto817-B2-371
dc.identifier.pmidPMC5848039
dc.identifier.pmid29564172


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