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dc.creatorRosero Bixby, Luis
dc.creatorRehkopf, David H.
dc.creatorDow, William H.
dc.creatorLin, Jue
dc.creatorEpel, Elissa S.
dc.creatorAzofeifa Navas, Jorge
dc.creatorLeal Esquivel, Alejandro
dc.date.accessioned2019-11-14T14:45:17Z
dc.date.available2019-11-14T14:45:17Z
dc.date.issued2019
dc.identifier.citationhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223766
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10669/79844
dc.description.abstractThe objective is to identify cofactors of leukocyte telomere length (LTL) in a Latin American population, specifically the association of LTL with 36 socio-demographic, early childhood, and health characteristics, as well as with DNA sample collection and storage procedures. The analysis is based on longitudinal information from a subsample of 1,261 individuals aged 60+ years at baseline from the Costa Rican Study of Longevity and Healthy Aging (CRELES): a nationally representative sample of elderly population. Random effects regression models for panel data were used to estimate the associations with LTL and its longitudinal changes. Sample collection procedures and DNA refrigerator storage time were strongly associated with LTL: telomeres are longer in blood collected in October-December, in DNA extracted from <1-year-old blood cells, and in DNA stored at 4°C for longer periods of time up to five years. The data confirmed that telomeres are shorter at older ages, as well as among males, and diabetic individuals, whereas telomeres are longer in the high-longevity Nicoya region. Most health, biomarkers, and early childhood indicators did not show significant associations with LTL. Longitudinal LTL variation over approximately two years was mainly associated with baseline LTL levels, as found in other studies. Our findings suggest that if there is unavoidable variability in season of sample collection and DNA storage time, these factors should be controlled for in all demographic and epidemiologic studies of LTL. However, due to unobserved components of measurement variation, statistical control may be inadequate as compared to standardization of data collection procedures.es_ES
dc.language.isoen_USes_ES
dc.sourcePLoS ONE, vol.14(10), pp.1-18es_ES
dc.subjectTelómeroses_ES
dc.subjectExtracción de ADNes_ES
dc.subjectConservación de ADNes_ES
dc.subjectBiomarcadoreses_ES
dc.subjectCosta Ricaes_ES
dc.titleCorrelates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedureses_ES
dc.typeartículo científico
dc.identifier.doi10.1371/journal.pone.0223766
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologíaes_ES


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