Quality verification of six medicines in wholes and halves tablets, re-packaged in individual plastic compartments during sixty days
artículo original
Fecha
2017Autor
Baudrit Carrillo, Olga
Baltodano Viales, Eleaneth
Jiménez Herrera, Luis Guillermo
Blanco Barrantes, Jeimy
Jiménez, María Fernanda
Metadatos
Mostrar el registro completo del ítemResumen
Plastic boxes with individual compartments are often used to improve
medication compliance and only a few studies have been done on the
stability of the tablet halves after placing them on these devices. In this
investigation, wholes and halves tablets of furosemide,
hydrochlorothiazide, spironolactone, warfarin sodium and atenolol and
levothyroxine sodium were re-packaged and storing for sixty days
under normal environmental conditions. The physical characteristics
were observed and the quality attributes were verified. There were no
changes in physical characteristics of all products. All products, except
halves tablets of atenolol, showed accuracy according the test of
uniformity of mass. The comparisons of dissolution profiles between
whole tablets and tablets halves were adequate for hydrochlorothiazide and atenolol, but not
for formulations of furosemide, spironolactone and warfarin sodium. Levothyroxine sodium
showed a different dissolution behavior than expected. Whole tablets of atenolol do not meet
specifications for uniformity of contents, neither the halves tablets of atenolol and
spironolactone. According to the results, it is possible to re-package wholes tablets of
furosemide, hydrochlorothiazide, spironolactone and warfarin sodium; but it is not advisable
to maintain this practice for whole tablets of atenolol and levothyroxine sodium, neither for
the halves of the rest of the products, except hydrochlorothiazide. These findings may
become opportunities for improvement for pharmaceutical laboratories, as well as become a
study topic for practitioners to advise the use of multi-compartment compliance aids, finally, these results should not be extrapolated to drugs, manufacturers, lots and conditions other
than those used in this study.
External link to the item
10.20959/wjpr201710-9438Colecciones
- Farmacia [178]