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dc.creatorBaudrit Carrillo, Olga
dc.creatorJiménez Herrera, Luis Guillermo
dc.date.accessioned2020-04-03T15:59:13Z
dc.date.available2020-04-03T15:59:13Z
dc.date.issued2017-08
dc.identifier.citationhttps://www.researchgate.net/profile/Olga_Baudrit/publications
dc.identifier.issn2277-7105
dc.identifier.urihttps://hdl.handle.net/10669/80868
dc.description.abstractTo elaborate the pediatric medicines the specifics of this population must be considered. Powder papers as extemporaneous formulations may be an option to provide dosing flexibility. The main objective of this research was to evaluate the quality of powder papers in its manual preparation stages and during the 60 days of storage. The results shown that a smaller than expected mass of tablets was distributed for the 40 papers at each formulation. The precision in the distribution performed by the crushed and pulverized tablet preparatory assistant reflected relative standard deviations ranging from 9 to 15%. On the start day, the uniformity of mass showed an inaccuracy reflected in several values outside the expected range, for all formulations. The accuracy of the tablets powder mass during storage at 60 days showed a ±10% of difference respect basal mass for papers with spironolactone 6,25 mg and the 15 and 75 mg amiodarone hydrochloride papers. For 10 mg of amiodarone hydrochloride formulation, random errors occurred outside the expected ranges at two sampling times. Powder adherence percentage was between the 10 and 20%. In conclusion, the preparation of four formulations in powder paper showed some errors which resulted in a significant loss of dose. A standardized operating procedure for the preparation of powder papers should be available taking into account the risk points of the manufacturing processes. It is advisable to enable the galenical section in hospital pharmacies and to have legislation regulating extemporaneous formulations in Costa Rica.es_ES
dc.language.isoen_USes_ES
dc.sourceWorld Journal of Pharmaceutical Research/ volumen 6, número 10, año 2017es_ES
dc.subjectExtemporaneouses_ES
dc.subjectpediatricses_ES
dc.subjectpowder paperses_ES
dc.subjectaccuracyes_ES
dc.subjectqualityes_ES
dc.titleQuality assessment in the extemporaneous pediatric preparation of powder papers containing crushed tablets of spironolactone or amiodaronees_ES
dc.typeartículo original
dc.identifier.doi10.20959/wjpr201710-9519
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)es_ES


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