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dc.creatorArias Arias, Jorge Luis
dc.creatorVega Aguilar, Francisco
dc.creatorPicado Soto, Dihalá
dc.creatorCorrales Aguilar, Eugenia
dc.creatorLoría Masís, Gilbert David
dc.date.accessioned2022-07-19T22:00:13Z
dc.date.available2022-07-19T22:00:13Z
dc.date.issued2021-09-15
dc.identifier.citationhttps://www.mdpi.com/journal/microbiolreses_ES
dc.identifier.issn2036-7481
dc.identifier.urihttps://hdl.handle.net/10669/86986
dc.description.abstractZika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant during recent outbreaks in Latin America due to its unrecognized association with fetal neurological disorders. Currently, there are no approved effective antivirals or vaccines for the treatment or prevention of ZIKV infections. Amantadine and rimantadine are approved antivirals used against susceptible influenza A virus infections that have been shown to have antiviral activity against other viruses, such as dengue virus (DENV). Here, we report the in vitro effectiveness of both amantadine and rimantadine hydrochlorides against ZIKV replication, resulting in a dose-dependent reduction in viral titers of a ZIKV clinical isolate and two different ZIKV reference strains. Additionally, we demonstrate similar in vitro antiviral activity of these drugs against DENV-1 and yellow fever virus (YFV), although at higher drug concentrations for the latter. ZIKV replication was inhibited at drug concentrations well below cytotoxic levels of both compounds, as denoted by the high selectivity indexes obtained with the tested strains. Further work is absolutely needed to determine the potential clinical use of these antivirals against ZIKV infections, but our results suggest the existence of a highly conserved mechanism across flavivirus, susceptible to be blocked by modified more specific adamantane compounds.es_ES
dc.description.sponsorshipCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceMocrobiology Research, 12, 2021es_ES
dc.subjectZikaes_ES
dc.subjectdenguees_ES
dc.subjectyellow feveres_ES
dc.subjectantiviralses_ES
dc.subjectadamantaneses_ES
dc.subjectamantadinees_ES
dc.subjectrimantadinees_ES
dc.titleIn Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorideses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi. https://doi.org/10.3390/microbiolres12030052
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiologíaes_ES


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