Show simple item record

dc.creatorDíaz Oreiro, Cecilia
dc.creatorQuesada Mora, Silvia
dc.creatorBrenes García, Oscar Gerardo
dc.creatorAguilar, Gilda
dc.creatorCicció Alberti, José Francisco
dc.date.accessioned2022-11-22T21:43:26Z
dc.date.available2022-11-22T21:43:26Z
dc.date.issued2008-11
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.urihttps://hdl.handle.net/10669/87733
dc.description.abstractThe leaf essential oil hydrodistilled from Schinus molle grown in Costa Rica was characterised in terms of its chemical composition, antioxidant activity, ability to induce cytotoxicity and the mechanism of cell death involved in the process. As a result, 42 constituents, accounting for 97.2% of the total oil, were identified. The major constituents of the oil were -pinene and -pinene. The antioxidant activity showed an IC50 of 36.3 mg mL 1 . The essential oil was cytotoxic in several cell lines, showing that it is more effective on breast carcinoma and leukemic cell lines. The LD50 for cytotoxicity at 48 h in K562 corresponded to 78.7 mg mL 1 , which was very similar to the LD50 obtained when apoptosis was measured. The essential oil did not induce significant necrosis up to 200 mg mL 1 , which together with the former results indicate that apoptosis is the main mechanism of toxicity induced by S. molle essential oil in this cell line. In conclusion, the essential oil tested was weak antioxidant and induced cytotoxicity in different cell types by a mechanism related to apoptosis. It would be interesting to elucidate the role that different components of the oil play in the effect observed here, since some of them could have potential anti-tumoural effects, either alone or in combination.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[422-A6-091]/UCR/Costa Ricaes_ES
dc.language.isoenges_ES
dc.sourceNational Product Research, Vol.22(17), pp.1521-1534es_ES
dc.subjectSchinus mollees_ES
dc.subjectAnacardiaceaees_ES
dc.subjectEssential oiles_ES
dc.subjectCytotoxicityes_ES
dc.subjectTumour cellses_ES
dc.subjectApoptosises_ES
dc.subjectBIOQUÍMICAes_ES
dc.titleChemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lineses_ES
dc.typeartículo originales_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.identifier.codproyecto422-A6-091


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record