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dc.creatorCao, Shugeng
dc.creatorMcMillin, Douglas W.
dc.creatorTamayo Castillo, Giselle
dc.creatorDelmore, Jake
dc.creatorMitsiades, Constantine S.
dc.creatorClardy, Jon
dc.date.accessioned2023-01-02T17:19:39Z
dc.date.available2023-01-02T17:19:39Z
dc.date.issued2012
dc.identifier.citationhttps://pubs.acs.org/doi/10.1021/np2009863es_ES
dc.identifier.issn0163-3864
dc.identifier.issn1520-6025
dc.identifier.urihttps://hdl.handle.net/10669/87967
dc.description.abstractCR1642D, an endophytic isolate of Penicillium sp. collected from a Costa Rican rainforest, was identified through a high-throughput approach to identify natural products with enhanced antitumor activity in the context of tumor–stromal interactions. Bioassay-guided separation led to the identification of five xanthones (1–5) from CR1642D. The structures of the xanthone dimer penexanthone A (1) and monomer penexanthone B (2) were elucidated on the basis of spectroscopic analyses, including 2D NMR experiments. All of the compounds were tested against a panel of tumor cell lines in the presence and absence of bone marrow stromal cells. Compound 3 was the most active, with IC50 values of 1–17 μM, and its activity was enhanced 2-fold against tumor cell line RPMI8226 in the presence of stromal cells (IC50 1.2 μM, but 2.4 μM without stromal cells).es_ES
dc.language.isoenges_ES
dc.sourceJournal of Natural Products, 75(4), p. 793-797es_ES
dc.subjectAlkylses_ES
dc.subjectAromatic compoundses_ES
dc.subjectMonomerses_ES
dc.subjectXanthoneses_ES
dc.subjectCELLSes_ES
dc.subjectCOSTA RICAes_ES
dc.titleInhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.es_ES
dc.typeartículo originales_ES
dc.identifier.doi10.1021/np2009863
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES


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