Microbiología
Envíos recientes
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Acute-phase reactions, including cytokines, in patients bitten by Bothrops and Crotalus snakes in Brazil
(1995)Thirty-one patients bitten by venomous snakes in Botucatu area (State of São Paulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, were studied. The group comprised twenty-nine males and ... -
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte 1)
(1995)Dentro del explosivo desarrollo en que se encuentra la inmunología básica, el campo de las citokinas y sus funciones dentro (y fuera) del sistema inmune, es uno de los que crece más vertiginosamente. En la primera parte ... -
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte II)
(1996)Las citokinas están interrelacionadas en una red funcional, la cual está finamente regulada. El balance en la producción de estas proteínas va a jugar un papel determinante en dirigir al sistema inmune hacia un determinado ... -
Phospholipase A 2 and inflammation
(1995)Increased expression of secreted group II phospholipase A 2 (sPLA2) is associated with inflammation 1.This enzyme can promote a variety of potentially harmful events, which have been attributed to its catalytic activity. ... -
Similar effectiveness of Fab and F(ab')2 antivenoms in the neutralization of hemorrhagic activity of Vipera berus snake venom in mice
(1996)The ability of two antivenoms to Vipera spp., consisting of Fab (Therapeutic Antibodies), or of F(ab′)2 (Zagreb Institute of Immunology) antibody fragments, to neutralize the hemorrhagic activity of Vipera berus snake venom ... -
Lys-49 phospholipases A2 as active enzymes for beta-arachidonoyl phospholipid bilayer membranes
(1997)Phospholipases A2 containing Lys-49 have been reported to be extremely weak or inactive as enzyme. We have recently shown that basic proteins I and II (BP-I and BP-II), Lys- 49-PLA2s isolated from the venom of Trimeresurus ... -
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice
(1996)The ability of pre-existing antibodies to neutralize locally-acting toxins of Bothrops asper snake venom was investigated. Hemorrhage, myonecrosis, and edema were markedly reduced in actively immunized mice, although ... -
Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom
(1995)A basic myotoxic protein was purified from Bothrops asper venom. Like other basic Bothrops myotoxins, myotoxin IV induces acute muscle damage after intramuscular injection in mice and disrupts negatively charged liposomes ... -
Neutralization of the cytolytic and myotoxic activities of phospholipases A2 from Bothrops asper snake venom by glycosaminoglycans of the heparin/heparan sulfate family
(1994)Basic phospholipases A2 from the venom of Bothrops asper exhibit skeletal muscle damaging activity in vivo, and cytolytic activity to a variety of cell types in culture. Glycosaminoglycans of the heparin/heparan sulfate ... -
The dynamics of local tissue damage induced by Bothrops asper snake venom and myotoxin II on the mouse cremaster muscle: an intravital and electron microscopic study
(1994-01)The acute tissue damaging effects of Bothrops riper snake venom and a myotoxic Lys-49 phospholipase A2 (myotoxin In on the mouse cremaster muscle were studied by intravital and electron microscopy. Both venom and myotoxin ... -
Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom
(1994)The cytotoxic activity of Bothrops asper myotoxin II, a lysine-49 phospholipase A2 isoform, on different cell types in culture, was investigated. Myotoxin II caused a dose-dependent cytolytic effect on all cell types tested, ... -
Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies
(1994)Eleven murine monocloncal antibodies (MAbs) against Micrurus nigrocinctus nigrocinctus venom were produced and partially characterized. When M. n. nigrocinctus venom proteins were separated by SDS-PAGE under non-reducing ... -
Electrophoretic and immunochemical studies of Micrurus venoms
(1994)The electrophoretic mobilities of venom components from 15 Micrurus species were studied by polyacrylamide gel electrophoresis. The venoms showed species-specific protein patterns under native (PAGE) or denaturing (urea-PAGE) ... -
Neutralizing interaction between heparins and myotoxin II, a Lys-49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling
(1994)Heparin binds to phospholipase A2 myotoxins from Bothrops asper snake venom, inhibiting their toxic activities. This interaction was investigated using purified myotoxin II, a Lys-49 phospholipase A2 of this venom, and a ... -
Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro
(1994)The effect of various crotalid and viperid venoms at 10, 50 and 100 μg/ml was examined on bovine and murine endothelial cells in vitro. The venoms caused the cells to lose their processes, leading to the appearance of ... -
Immunoenzymatic quantitation of antibodies to Bothrops asper myotoxins after polyvalent antivenom administration in mice.
(1992)Two quantitative enzyme-immunoassays (EIA) for Bothrops asper myotoxin and anti-myotoxin antibodies, respectively, were utilized to study their in vivo distribution in mice (Swiss, 18 to 20 g). 2. After polyvalent antivenom ...
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