Microbiología
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Determinación de la prevalencia del rasgo heterocigoto para hemoglobina S en las unidades de glóbulos rojos empacados utilizadas en el Hospital Nacional de Niños entre los meses de mayo y octubre del 2019
(2020)La drepanocitosis es una enfermedad de relativa alta frecuencia en nuestro país y en el mundo en general, estos pacientes sufren de anemia hemolítica crónica y constantes complicaciones que requieren de frecuentes ... -
New Diet Quality Index of children and adolescents in Costa Rica
(2020)Introduction: There is an increasing interest in the study of indicators of the quality of the total diet through the study of food groups of certain dietary patterns. Objective: Analyze the diet of students of Costa Rica ... -
Exposure of dogs to Rickettsia spp. in Costa Rica: Risk factors for PCR-positive ectoparasites and seropositivity
(2019)Infection of dogs with Rickettsia spp. can result in inapparent, mild, or severe disease. Moreover, common dog ticks and fleas are able to transmit rickettsiae to nearby humans. In this study, the seroprevalence of spotted ... -
Resistencia de Aedes Aegypti (Diptera: Culicidae) a insecticidas organofosforados y piretroides en la localidad de Orotina, Alajuela, Costa Rica
(2019)Objetivos: Determinar la resistencia de una cepa de Aedes. aegypti de Orotina a insecticidas organofosforados (temefós y malatión), y a piretroides (deltametrina, lambda cialotrina y cipermetrina). Métodos: La evaluación ... -
Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
(2019)Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence ... -
Brucella Genetic Variability in Wildlife Marine Mammals Populations Relates to Host Preference and Ocean Distribution
(2017)Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ... -
The gut microbiome of the neotropical beetle Veturius sp. (coleoptera: passalidae): structure, composition and geneticpotential for cellulose degradation
(2020)The global carbon cycle is responsible for maintaining the carbon dioxide and methane concentration in the atmosphere, influencing the weather and ocean acidification. Herbivores play an important role in the carbon cycle. ... -
Cimex lectularius Linnaeus, 1758 (Hemiptera: Cimicidae) in Costa Rica: First Case Report Confirmed by Molecular Methods in Central America
(2020)Cimex lectularius and Cimex hemipterus are the most common species of bedbugs that infest homes. Although case reports decreased substantially by the end of the 20th century, bed bugs, and especially C. lectularius, are ... -
Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): composition, biochemical activities and in vivo toxicity for potential prey
(2019)In this study, we characterize the venom of Centruroides edwardsii, one of the most abundant scorpions in urban and rural areas of Costa Rica, in terms of its biochemical constituents and their biological activities. C. ... -
Enzymatic labelling of venom phospholipase A2 toxins
(2019)Almost all animal venoms contain secretory phospholipases A2 (PLA2s), 14 kDa disulfide-rich enzymes that hydrolyze membrane phospholipids at the sn-2 position, releasing lysophospholipids and fatty acids. These proteins, ... -
Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: phylogenetic relationships and characterization of Clarkitoxin-I-Mdum
(2019)Micrurus mipartitus and M. dumerilii are the most medically important coral snakes in Colombia. Proteomic characterization of their venoms has previously shown that proteins of the three-finger toxin (3FTx) family ... -
A secreted phospholipase A2 induces formation of smooth muscle foam cells which trans-differentiate to macrophage-like state
(2019)Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A2s (GIIA sPLA2s) are highly expressed in VSMCs, but ... -
Transfección mediante vehículos génicos basados enhidroxiapatita: eficacia y efectos sobre el tráfico intracelular
(2019)La hidroxiapatita (HAp), Ca10(PO4)6(OH)2, es un mineral miembro de las apatitas con una razón Ca/P de 1,67. Es el principal componente mineral de los huesos en los vertebrados y posee una serie de características de interés ... -
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
(2019)Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation ... -
Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: comparative characterization and synergism between Asp49 and Lys49 variants
(2019)Bothrops diporus, previously considered a subspecies of the B. neuwiedi complex, is a medically relevant viperid in Northeastern Argentina. The venom of this species causes local tissue damage characterized by ... -
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
(2019)Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes are ... -
New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America
(2019)Micrurus is a monophyletic genus of venomous coral snakes of the family Elapidae. The ~80 recognized species within this genus are endemic to the Americas, and are distributed from southeastern United States to ... -
Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica
(2019)The genus Porthidium includes nine pitviper species inhabiting Mexico, Central America, and northern South America. Porthidium porrasi is a species endemic to the Southwest of Costa Rica, for which no information on ... -
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom
(2019)A proteomic and toxicological study of the venom from one specimen of Micrurus ruatanus, a critically endangered coral snake species endemic to Roatan Island, Honduras, was carried out. Immunorecognition and neutralization ... -
Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro
(2019)non-buthid venoms, for which knowledge is scarce. In this work, we characterized the venom of a Diplocentridae species, Didymocentrus krausi, a small fossorial scorpion that inhabits the Tropical Dry Forest of Central ...
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