Microbiología
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Cardiac effect induced by Crotalus durissus cascavella venom: morphofunctional evidence and mechanism of action
(2021)Envenoming, resulting from snake bites, is a global public health problem. The present study was undertaken to investigate the influence of Crotalus durissus cascavella (Cdcas) venom on cardiac activity and the mechanisms ... -
The earless monitor lizard Lanthanotus borneensis – a venomous animal?
(2021)Based on its mandibular gland secretion, the earless monitor lizard, Lanthanotus borneensis, has been considered a venomous animal like other members of the Toxicofera group, including Heloderma. In the present study, the ... -
Genetic and toxinological divergence among populations of Tityus trivittatus Kraepelin, 1898 (Scorpiones: Buthidae) inhabiting Paraguay and Argentina
(2020)Envenoming by scorpions in genus Tityus is a public health problem in Tropical America. One of the most medically significant species is Tityus trivittatus, which is known to occur from southwest Brazil to central-northern ... -
Preadipocytes are target cells for the actions of a representative gIIA phospholipase A2 which triggers proinflammatory pathways related to obesity
(2020)Adipose tissue secretes proinflammatory mediators which promote systemic and adipose tissue inflammation seen in obesity. Group IIA (GIIA)-secreted phospholipase A2 (sPLA2) enzymes are found to be elevated in plasma and ... -
Caracterización clínica y de los hallazgos en líquido cefalorraquídeo, de pacientes inmunocompetentes e inmunosupresos, con meningitis o encefalitis viral, diagnosticados por métodos moleculares en el Hospital San Juan de Dios, en el período de enero del 2018 a junio del 2020
(2021-03)Justificación y objetivos: Las infecciones del Sistema Nervioso Central suponen un problema importante de salud. En Costa Rica, existen vacíos importantes en torno a los datos de los casos de meningitis y encefalitis de ... -
Immunological cross-recognition and neutralization studies of Micrurus mipartitus and Micrurus dumerilii venoms by two therapeutic equine antivenoms
(2020)New world Coral snakes comprise 82 species of medical importance distributed from southeastern United States to Argentina. In Colombia, Micrurus mipartitus and M. dumerilii are responsible for most coral snakebite accidents. ... -
Venom variation in Bothrops asper lineages from north-western South America.
(2020)Bothrops asper is a venomous pitviper that is widely distributed and of clinical importance in Mesoamerica and northern South America, where it is responsible for 50–80% of all envenomations by Viperidae species. Previous ... -
Danger in the canopy: comparative proteomics and bioactivities of the venoms of the South American palm viper Bothrops bilineatus subspecies bilineatus and smaragdinus, and antivenomics of B. b. bilineatus (Rondônia) venom against the Brazilian pentabothropic antivenom
(2020)We report a structural and functional proteomics characterization of venoms of the two subspecies (Bothrops bilineatusbilineatus and B. b. smaragdinus) of the South American palm pit viper from the Brazilian state of ... -
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy
(2020)In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, ... -
Venomics of the Duvernoy's gland secretion of the false coral snake Rhinobothryum bovallii (Andersson, 1916) and assessment of venom lethality towards synapsid and diapsid animal models
(2020)The Duvernoy's gland secretory proteome of the false coral snake Rhinobothryum bovallii (Costa Rica), unveiled applying bottom-up venomics, comprises a handful of toxins belonging to only three protein families, three-finger ... -
Ontogenetic variation in the venom of Mexican Jumping Viper (Metlapilcoatlus nummifer)
(2020)The viperid genus Metlapilcoatlus (previously Atropoides) is represented in Mexico by four species: M. olmec, M. mexicanus, M. occidus, and M. nummifer. To date, no studies on their venoms have been reported. Here, we ... -
An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity
(2020)Snakebite envenoming is a major neglected tropical disease that affects millions of people every year. The only effective treatment against snakebite envenoming consists of unspecified cocktails of polyclonal antibodies ... -
Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: identification of the first lethal multimeric neurotoxin in coral snake venom
(2020)Proteomic characterization of Micrurus browni browni venom showed approximately 41 components belonging to 9 protein families, mainly phospholipases A2 (PLA2s) and three-finger toxins (3FTxs). Venom gland transcriptome ... -
A lipidomic perspective of the action of group IIA secreted phospholipase A2 on human monocytes: lipid droplet biogenesis and activation of cytosolic phospholipase A2α
(2020)Phospholipase A2s constitute a wide group of lipid-modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry-based lipidomic approaches to investigate ... -
Comparative biochemical characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression
(2020)Snake species within the Bothrops complex (sensu lato) are of medical relevance in Latin America, but knowledge on their venom characteristics is limited, or even unavailable, for some taxa. Perú harbors 17 species of pit ... -
Editorial: Novel immunotherapies against envenomings by snakes and other venomous animals
(2020)Editorial on the Research Topic -
Development of nanobodies against hemorrhagic and myotoxic components of Bothrops atrox snake venom
(2020)Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites. Although effective against systemic effects, conventional ... -
Unity makes strength: exploring intra and interspecies toxin synergism between phospholipases A2 and cytotoxins
(2020)Toxin synergism is a complex biochemical phenomenon, where different animal venom proteins interact either directly or indirectly to potentiate toxicity to a level that is above the sum of the toxicities of the individual ... -
Venomics of the Central American Lyre snake Trimorphodon quadruplex (Colubridae: Smith, 1941) from Costa Rica
(2020)Rear-fanged colubrid snakes include hundreds of species globally that possess a Duvernoy's venom gland and often one-several enlarged rear maxillary teeth. We investigated the venom proteome of the Central American Lyre ... -
Venom diversity in the neotropical genus Tityus: implications for antivenom design emerging from molecular and immunochemical analyses across endemic areas of scorpionism
(2020)Scorpions of the Neotropical genus Tityus are responsible for most severe envenomations in the Caribbean, South America, and Lower Central America (LCA). Although Tityus is taxonomically complex, contains high toxin ...
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