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dc.creatorMoreno Robles, Edgardoes_ES
dc.creatorGutiérrez, José Maríaes_ES
dc.date.accessioned2016-11-04T22:06:54Zes_ES
dc.date.available2016-11-04T22:06:54Zes_ES
dc.date.issued1988es_ES
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/0041010188900098es_ES
dc.identifier.issn0041-0101es_ES
dc.identifier.urihttp://hdl.handle.net/10669/29151es_ES
dc.description.abstractThe distribution of 125I-labelled Bothrops asper myotoxin following i.m. and i.v. injections was studied in mice. After i.m. administration the toxin was concentrated in the injected gastrocnemius muscle, with relatively little binding to other tissues. Upon i.v. injection the highest radioactivity was detected in liver, kidneys, lungs, spleen and blood. A conspicuous decrease in myotoxin concentration occurred during the first hour, whereas the rate of decrease was reduced at later time periods. Only the injected skeletal muscle was clearly damaged after i.m. inoculation, as judged by histology and by the decrease in tissue creatine kinase contents. Contralateral, noninjected gastrocnemius was not affected by the toxin. Histological observations carried out after i.v. administration of the toxin revealed moderate alterations only in lungs, with a slight increase in serum levels of the enzymes creatine kinase and alanine aminotransferase.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 26, Número 4, 1988es_ES
dc.subjectAlanine Transaminasees_ES
dc.subjectAnimalses_ES
dc.subjectAspartate Aminotransferaseses_ES
dc.subjectCreatine Kinasees_ES
dc.subjectCrotalid Venomses_ES
dc.subjectInjectionses_ES
dc.subjectIodine Radioisotopeses_ES
dc.subjectMuscleses_ES
dc.subjectTissue Distributiones_ES
dc.subjectSnake venomes_ES
dc.titleBody distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/0041-0101(88)90009-8es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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