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Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species

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Gutiérrez, José María
Lomonte, Bruno
Portilla Brizuela, Elsa
Cerdas Fallas, Luis
Rojas Umaña, Ermila

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Abstract

The local effects induced by intramuscular inoculations of venons from six species of coral snakes were studied in mice. Venoms of Micrurus nlgrocinctus nigrocinctus, M. n . moquitensis, M. alleni, M. frontalis, M. aarinkauda and M. surinamensis induced prominent myonecrosis which was observed histologically. From a morphological point of view all these venons induced a similar pattern of myonecrosis, characterized by a conspicuous alteration of the intracellular structure . This myotoxic activity was corroborated by an increase in plasma creatine kinase levels 3 hr after i .m . injection of M. n. nlgrocinctus , M. n . mosquitensis, M. frontalis and M. carinicauda venoms. M. mipartitus venom did not induce myonecrosis. None of the venoms induced edema or hemorrhage at the site of injection.

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Micrurus, mionecrosis, Veneno de serpiente

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http://www.sciencedirect.com/science/article/pii/0041010183900661

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