Logo Kérwá
 

Proteoform-resolved quantitative venomics: looking through a crystal ball

Loading...
Thumbnail Image

Authors

Calvete Chornet, Juan José
Petras, Daniel
Calderón Celis, Francisco
Lomonte, Bruno
Ruiz Encinar, Jorge
Sanz Medel, Alfredo

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects

Description

Keywords

Top-down proteomics, Top-down venomics, Protein species resolved venomic, Absolute quantification, Inductively coupled plasma mass spectrometry, Snake venom

Citation

https://jvat.biomedcentral.com/articles/10.1186/s40409-017-0116-9

Collections

Endorsement

Review

Supplemented By

Referenced By

Creative Commons license

Except where otherwised noted, this item's license is described as acceso abierto