Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments
Loading...
Date
Authors
Mike, Laura A.
Tripathi, Ashootosh
Blankenship, Connor M.
Saluk, Alyssa
Schultz, Pamela J.
Tamayo Castillo, Giselle
Sherman, David H.
Mobley, Harry L. T.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.
Description
Keywords
Nicoyamycin A, Escherichia coli, Inhibitor, Antibiotics, Bacterial infections
Citation
https://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07732g#!divAbstract