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Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments

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Mike, Laura A.
Tripathi, Ashootosh
Blankenship, Connor M.
Saluk, Alyssa
Schultz, Pamela J.
Tamayo Castillo, Giselle
Sherman, David H.
Mobley, Harry L. T.

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Abstract

High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections.

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Nicoyamycin A, Escherichia coli, Inhibitor, Antibiotics, Bacterial infections

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https://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07732g#!divAbstract

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