Logo Kérwá
 

Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction

Loading...
Thumbnail Image

Date

Authors

Cornelis, Marilyn C.
El-Sohemy, Ahmed
Campos Núñez, Hannia

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by cytochrome P450 (CYP) 1A1 or CYP1A2. The objective of this study was to determine the effects of CYP1A1 and CYP1A2 genotypes on risk of myocardial infarction (MI) and whether smoking interacts with genotype to modify risk.

Description

Keywords

Tabaco, infarto de miocardio, enfermedad coronaria

Citation

https://jmg.bmj.com/content/41/10/758

Endorsement

Review

Supplemented By

Referenced By