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dc.creatorPineda Cedeño, Leslie William
dc.creatorArias Echandi, María Laura
dc.creatorCabezas Pizarro, Jorge A.
dc.date.accessioned2020-08-06T18:56:43Z
dc.date.available2020-08-06T18:56:43Z
dc.date.issued2019
dc.identifier.citationhttps://onlinelibrary.wiley.com/iucr/doi/10.1107/S2053229619016127es_ES
dc.identifier.issn2053-2296
dc.identifier.urihttp://hdl.handle.net/10669/81415
dc.description.abstract1,3-Enyne structural motifs are versatile building blocks in organic synthesis and occur widely in various natural products with many of them being highly active as cytotoxic macrolides and antitumour antibiotics. This article presents the crystal structure of three 1,1,4-triphenyl-substituted 1,3-enynes, viz. 4-(2- methylphenyl)-1,1-diphenylbut-1-en-3-yne, C23H18 (1), 4-(2-methoxyphenyl)-1,1- diphenylbut-1-en-3-yne, C23H18O (2), and 4-(4-nitrophenyl)-1,1-diphenylbut-1- en-3-yne, C22H15NO2 (3). The benzene ring at position 4 of the but-1-en-3-yne group bears a weakly activating methyl group in compound 1, a moderately activating methoxy group in 2 and a strongly deactivating nitro group in 3. The crystal structures of 1 and 3 both have monoclinic symmetry, while that of 2 is orthorhombic, and all of them have one molecule in the asymmetric unit. All three compounds were investigated for their antibacterial and antifungal activities. Interestingly, enyne 2 is the only compound tested that inhibited the growth of Aspergillus niger.es_ES
dc.language.isoen_USes_ES
dc.sourceActa Cryst., vol.C76(1), pp.87–92es_ES
dc.subjectProductos naturaleses_ES
dc.subjectActividad antifúngicaes_ES
dc.subjectEstructura cristalinaes_ES
dc.subject1,3-dili­thio­propynees_ES
dc.subject1,3-enynees_ES
dc.subjectAnti­bacterial activityes_ES
dc.subjectCrystal structurees_ES
dc.subjectAnti­fungal activityes_ES
dc.subjectNatural productses_ES
dc.titleCrystal structures and biological activity of 1,1,4-tri­phenyl-substituted 1,3-enyne com­poundses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1107/S2053229619016127
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Electroquímica y Energía Química (CELEQ)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)es_ES


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