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Crystal structures and biological activity of 1,1,4-triphenyl-substituted 1,3-enyne compounds
dc.creator | Pineda Cedeño, Leslie William | |
dc.creator | Arias Echandi, María Laura | |
dc.creator | Cabezas Pizarro, Jorge A. | |
dc.date.accessioned | 2020-08-06T18:56:43Z | |
dc.date.available | 2020-08-06T18:56:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | https://onlinelibrary.wiley.com/iucr/doi/10.1107/S2053229619016127 | |
dc.identifier.issn | 2053-2296 | |
dc.identifier.uri | https://hdl.handle.net/10669/81415 | |
dc.description.abstract | 1,3-Enyne structural motifs are versatile building blocks in organic synthesis and occur widely in various natural products with many of them being highly active as cytotoxic macrolides and antitumour antibiotics. This article presents the crystal structure of three 1,1,4-triphenyl-substituted 1,3-enynes, viz. 4-(2- methylphenyl)-1,1-diphenylbut-1-en-3-yne, C23H18 (1), 4-(2-methoxyphenyl)-1,1- diphenylbut-1-en-3-yne, C23H18O (2), and 4-(4-nitrophenyl)-1,1-diphenylbut-1- en-3-yne, C22H15NO2 (3). The benzene ring at position 4 of the but-1-en-3-yne group bears a weakly activating methyl group in compound 1, a moderately activating methoxy group in 2 and a strongly deactivating nitro group in 3. The crystal structures of 1 and 3 both have monoclinic symmetry, while that of 2 is orthorhombic, and all of them have one molecule in the asymmetric unit. All three compounds were investigated for their antibacterial and antifungal activities. Interestingly, enyne 2 is the only compound tested that inhibited the growth of Aspergillus niger. | es_ES |
dc.language.iso | en_US | es_ES |
dc.source | Acta Cryst., vol.C76(1), pp.87–92 | es_ES |
dc.subject | Productos naturales | es_ES |
dc.subject | Actividad antifúngica | es_ES |
dc.subject | Estructura cristalina | es_ES |
dc.subject | 1,3-dilithiopropyne | es_ES |
dc.subject | 1,3-enyne | es_ES |
dc.subject | Antibacterial activity | es_ES |
dc.subject | Crystal structure | es_ES |
dc.subject | Antifungal activity | es_ES |
dc.subject | Natural products | es_ES |
dc.title | Crystal structures and biological activity of 1,1,4-triphenyl-substituted 1,3-enyne compounds | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1107/S2053229619016127 | |
dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Electroquímica y Energía Química (CELEQ) | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET) | es_ES |
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