Listar Investigación por autor "1212ef26-752c-47bd-a6ed-03c101ea6dee"
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Helicobacter pylori Colonization Drives Urokinase Receptor (uPAR) Expression in Murine Gastric Epithelium During Early Pathogenesis
Alpízar Alpízar, Warner; Skindersoe, Mette Elena; Rasmussen, Lone; Kriegbaum, Mette Camila; Christensen, Ib J.; Lund, Ida Katrine; Illemann, Martin; Laerum, Ole Didrik; Krogfelt, Karen Angeliki; Andersen, Leif Percival; Ploug, Michael (2020)(1) Background: Persistent Helicobacter pylori infection is the most important risk factor for gastric cancer. The urokinase receptor (uPAR) is upregulated in lesions harboring cancer invasion and inflammation. Circumstantial ... -
Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy
Eefsen, Rikke Loevendahl; Engelholm, L.; Alpízar Alpízar, Warner; Van den Eynden, Gert G. E.; Vermeulen, Peter B.; Christensen, Ib J.; Laerum, Ole Didrik; Rolff, Hans Christian; Høyer Hansen, Gunilla; Vainer, B.; Osterlind, Kell; Illemann, Martin (2015-08-14)Proteolytic activity and inflammation in the tumour microenvironment affects cancer progression. In colorectal cancer (CRC) liver metastases it has been observed that three different immune profiles are present, as well ... -
Neutrophil gelatinase-associated lipocalin (NGAL/Lcn2) is upregulated in gastric mucosa infected with Helicobacter pylori
Alpízar Alpízar, Warner; Didrik Laerum, Ole; Illemann, Martin; Ramírez Corrales, José Alberto; Arias, Adriana; Malespín Bendaña, Wendy Karina; Ramírez Mayorga, Vanessa; Lund, Leif R.; Borregaard, Niels; Schnack Nielsen, Boye (2009-09)Helicobacter pylori infection is one of the most significant risk factors for gastric cancer. The infection is established early in life and persists lifelong leading to a sustained chronic inflammation. Iron is essential ... -
Tissue Inhibitor of Metalloproteinase-1 Is Confined to Tumor-Associated Myofibroblasts and Is Increased With Progression in Gastric Adenocarcinoma
Alpízar Alpízar, Warner; Didrik Laerum, Ole; Christensen, Ib J.; Ovrebo, Kjell; Skarstein, Arne; Høyer Hansen, Gunilla; Ploug, Michael; Illemann, Martin (2016)The tissue inhibitor of metalloproteinase-1 (TIMP-1) inhibits the extracellular matrix–degrading activity of several matrix metalloproteinases, thereby regulating cancer cell invasion and metastasis. Studies describing the ... -
Urokinase plasminogen activator receptor is expressed in invasive cells in gastric carcinomas from high- and low-risk countries
Alpízar Alpízar, Warner; Schnack Nielsen, Boye; Sierra Ramos, Rafaela; Illemann, Martin; Ramírez, José A.; Arias, Adriana; Durán, Sundry; Skarstein, Arne; Ovrebo, Kjell; Lund, Leif R.; Laerum, Ole Didrik (International Journal of Cancer 146 año 2009 p. 405–415, 2009-07-16)Gastric cancer is the second cancer causing death worldwide. Both incidence and mortality rates vary according to geographical regions. The receptor for urokinase plasminogen activator (uPAR) is involved in extracellular ...