Listar Investigación por autor "610169ed-cccd-4ad0-8df7-5849f7b8fd1f"

Mostrando ítems 1-20 de 64

    • A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity 

      Ymele Leki, Patrick; Cao, Shugeng; Sharp, Jared ; Lambert, Kathleen G.; McAdam, Alexander J.; Husson, Robert N.; Tamayo Castillo, Giselle ; Clardy, Jon; Watnick, Paula I. (2012)
      Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and ...

    • Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts 

      Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi; MacArthur, Ryan; Dranchak, Patricia; Chlipala, George E.; Okoneski, Matthew T.; Guha, Rajarshi; Eastman, Richard T.; Yuan, Jing; Schultz, Pamela J.; Su, Xin-zhuan; Tamayo Castillo, Giselle; Matainaho, Teatulohi; Clardy, Jon; Sherman, David H.; Inglese, James (2015)
      Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...

    • Adipostatins E-J, new potent antimicrobials identified as inhibitors of coenzyme-A biosynthesis 

      Gómez Rodríguez, Lyanne; Schultz, Pamela J.; Tamayo Castillo, Giselle; Dotson, Garry D.; Sherman, David H.; Tripathi, Ashootosh (2020-01)
      Phosphopantetheine is a key structural element in biological acyl transfer reactions found embedded within coenzyme A (CoA). Phosphopantothenoylcysteine synthetase (PPCS) is responsible for installing a cysteamine group ...

    • Alkaloid contents in members of Lycopodiales 

      Tamayo Castillo, Giselle; Romero Chacón, Rosaura María; Rosales Ovares, Kattia; Jiménez Ardón, Allan Miguel; Jiménez Somarribas, Alberto; Montenegro, Héctor; Rodríguez Arrieta, Jesús Alexander; Vargas, Luis Diego (2001)
      The composition of alkaloids in fifteen species that belong to the Lycopodiales, which grow wild in Costa Rica were analysed by gas chromatography coupled with mass spectrometry. Several alkaloids were identified, ...

    • Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis 

      Tripathi, Ashootosh; Schofield, Michael M.; Chlipala, George E.; Schultz, Pamela J.; Yim, Isaiah; Newmister, Sean A.; Nusca, Tyler D.; Scaglione, Jamie B.; Hanna, Philip C.; Tamayo Castillo, Giselle; Sherman, David H. (2014)
      Siderophores are high-affinity iron chelators produced by microorganisms and frequently contribute to the virulence of human pathogens. Targeted inhibition of the biosynthesis of siderophores staphyloferrin B of Staphylococcus ...

    • Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC 

      Sáenz Castillo, Antonio; Sanabria Chinchilla, Jean; García Piñeres, Alfonso J.; Tamayo Castillo, Giselle (2022)
      A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined in ...

    • Biodiversity for Bioindustries 

      Tamayo Castillo, Giselle; Nader, Werner F.; Sittenfeld Appel, Ana (1997)
      Biodiversity refers to the variety and variability of living material and ecological complexes in a given area and comprises species, genetic and ecosystem diversity. Biodiversity is not only the basis of life on earth, ...

    • Biodiversity Prospecting: The INBio Experience 

      Tamayo Castillo, Giselle; Guevara Fernández, Ana Lorena; Gámez Lobo, Rodrigo (2004)
      Bioprospecting is defined as the systematic search for genes, compounds, designs, and organisms that might have a potential economic use and might lead to a product development. In 1991, Costa Rica's National Institute of ...

    • Bioprospecting 

      Mateo, Nicolás; Nader, Werner F.; Tamayo Castillo, Giselle (2001)
      Bioprospecting is the systematic search for genes, natural compounds designs and whole organisms in wild life with a potential for product development by biological observation and biophsical, biochemical, and genetic ...

    • Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis 

      Sidhu, Alpa; Miller, Justin R.; Tripathi, Ashootosh; Garshott, Danielle M.; Brownell, Amy L.; Chiego, Daniel J.; Arevang, Carl Johan; Zeng, Qinghua; Jackson, Leah C.; Bechler, Shelby A.; Callaghan, Michael U.; Yoo, George H.; Sethi, Seema; Lin, Ho-Sheng; Callaghan, Joseph H.; Tamayo Castillo, Giselle; Sherman, David H.; Kaufman, Randal J.; Fribley, Andrew M. (2015)
      Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral cavity, and US clinics will register about 30,000 new patients in 2015. Current treatment modalities include chemotherapy, surgery, and ...

    • Clibadiolide, a sesquiterpene lactone esterified with a homoditerpene from Clibadium pittierii 

      Tamayo Castillo, Giselle; Jakupovic, Jasmin; Bohlman, F.; Castro Araya, Víctor H. (1988)
      The aerial parts of Clibadium pittierii afforded in addition to known melampolides two new ones, one being esterified with a homoditerpenic acid and the homoditerpenic acid itself. The structures were elucidated by high ...

    • Costa rican international cooperative biodiversity group: using insects and other arthropods in biodiversity prospecting 

      Sittenfeld Appel, Ana; Tamayo Castillo, Giselle; Nielsen Muñoz, Vanessa; Jiménez Ardón, Allan Miguel; Hurtado Hernández, Priscilla; Chinchilla Carmona, Misael; Guerrero Bermúdez, Olga Marta; Mora, María Auxiliadora; Rojas, Miguel; Blanco, Roger; Alvarado, Eugenio; Gutiérrez, José María; Janzen, Daniel Hunt (Pharmaceutical Biology 37(Supplement):55–68. 1999, 1999)
      This paper describes the Costa Rican International Collaborative Biodiversity Group (ICBG), which was designed to introduce insects and other arthropods as a source of pharmaceutical compounds, and to generate knowledge ...

    • Costa Rican Propolis Chemical Compositions: Nemorosone Found to Be Present in an Exclusive Geographical Zone 

      Umaña Rojas, Eduardo; Solano Arias, Godofredo; Zamora Fallas, Luis Gabriel; Tamayo Castillo, Giselle (2023-10-14)
      Background: The chemistry of Costa Rican propolis from Apis mellifera remains underexplored despite its potential applications. This study identified its chemical composition, linking chemotypes to antioxidant potential. ...

    • Differential volatile organic compound expression in the interaction of Daldinia eschscholtzii and Mycena citricolor 

      Escudero Leyva, Efraín; Quirós Guerrero, Luis Manuel; Vásquez Chaves, Víctor; Pereira Reyes, Reinaldo; Chaverri Echandi, Priscila; Tamayo Castillo, Giselle (2023)
      Fungi exhibit a wide range of ecological guilds, but those that live within the inner tissues of plants (a.k.a. endophytes) are particularly relevant due to the benefits they sometimes provide to their hosts, such as ...

    • Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A 

      Lee, Seulah; Tamayo Castillo, Giselle; Pang, Changhyun; Clardy, Jon; Cao, Shugeng; Kim, Ki Hyun (2016-05-15)
      Three new diketopiperazines (1–3), cyclo(l-Pro-d-trans-Hyp) (1), cyclo(l-Pro-d-Glu) (2), and cyclo(d-Pro-d-Glu) (3) and five known diketopiperazines (4–8) were isolated from the endolichenic fungus Colpoma sp. CR1465A ...

    • Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway 

      Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng; Schultz, Pamela J.; Yim, Isaiah; McQuade, Thomas J.; Yu, Fengan; Arevang, Carl Johan; Mensah, Abraham Y.; Tamayo Castillo, Giselle; Xi, Chuanwu; Sherman, David H. (2016-02-16)
      Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix where they colonize to form a biofilm. This cellular superstructure can display increased resistance to antibiotics and ...

    • Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments 

      Mike, Laura A.; Tripathi, Ashootosh; Blankenship, Connor M.; Saluk, Alyssa; Schultz, Pamela J.; Tamayo Castillo, Giselle; Sherman, David H.; Mobley, Harry L. T. (2017)
      High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal ...

    • Diterpenes and sesquitrpenes from Mikania banisteriae 

      Lobitz, G. O.; Tamayo Castillo, Giselle; Merfort, Irmgard (1997)
      Two new ent-kaurane diterpenes, 18,19-diacetoxy-ent-kaur-16-ene and 17-oxo-ent-kaur-15(16)-en-18-oic acid, were isolated from the aerial parts of Mikania banisteriae, together with the known ent-kauranes ent-kaur-16-en-18-oic ...

    • Diterpenes from Fleischmannia hymenophylla and Brickellia laciniata 

      Jakupovic, Jasmin; Tsichritzis, Fotini; Tamayo Castillo, Giselle; Castro Araya, Víctor H.; Bohlmann, Ferdinand; Boldt, E. (1989)
      The aerial parts of Fleischmannia hymenolepis gave in addition to phytol and sesamin a new derivative of beyerene named hymenophylloide. The aerial parts of Brickellia laciniata afforded several new labdane derivatives and ...

    • Efecto de extractos de artrópodos sobre la multiplicación del Toxoplasma gondii dentro de macrófagos peritoneales de ratón 

      Chinchilla Carmona, Misael; Herrera Corrales, Marlen; Guerrero Bermúdez, Olga Marta; Jiménez Somarribas, Alberto; Tamayo Castillo, Giselle; Sittenfeld Appel, Ana; Nielsen Muñoz, Vanessa; Hurtado Hernández, Priscilla (Rev. Biol. Trop. 51(2): 317-320, 2003, 2003)
      Treatment of toxoplasmosis usually causes secondary effects. It is important to find active substances extracted from natural organisms. In this work we studied some arthropod extracts that have effect against Toxoplasma ...