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No sea egoísta, use mascarilla
(2020-04-08)El uso de mascarillas en público evitaría en Costa Rica más de 3.000 muertes en los seis meses venideros. Taparse la nariz y la boca no es tanto para protegernos del otro, sino para proteger al otro. -
Nociones de Inmunologia
(2018)La primera versión de este breve texto nació en 1990, con el objetivo de presentar al estudiante una visión rápida de los principios generales de la Inmunología, a un nivel introductorio. El texto está dirigido principalmente ... -
Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines
(2007)Disability and mortality resulting from cardiovascular disease (CVD) are on the rise in many developing countries, partly because of the nutritional transition and westernization of lifestyles. Developing countries account ... -
Norrie Disease Gene Mutation in a Large Costa Rican Kindred With a Novel Phenotype Including Venous Insufficiency
(1997)A large Costa Rican kindred has been identified with 15 males affected with congenital blindness, progressive hearing loss, and venous insufficiency. Due to ophthalmological and audio-otological findings, including bilateral ... -
Not just the lack of food
(1977)Whose who are familiar with rural areas of developing nations are often amazed to tind malnourished children in families where food is available in amounts sufficient to ensure an adequate diet. There may seem to be plenty ... -
Novel catalytically-inactive PII metalloproteinases from a viperid snake venom with substitutions in the canonical zinc-binding motif
(2016-10-12)Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates in the tissues. Hereby, we ... -
Novel Clade C-I Clostridium difficile strains escape diagnostic tests, differ in pathogenicity potential and carry toxins on extrachromosomal elements
(2018)The population structure of Clostridium difficile currently comprises eight major genomic clades. For the highly divergent C-I clade, only two toxigenic strains have been reported, which lack the tcdA and tcdC genes and ... -
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: A biochemical and immunohistochemical study
(2016-11-15)The hemorrhagic activity characteristic of viperid snake envenomations is due to the action of venom metalloproteinases (SVMPs) on the capillary vessel basement membrane (BM). This study compared the action of two SVMPs ... -
Novel Mutations in the MYOC/GLC1A Gene in a Large Group of Glaucoma Patients
(Human Mutant ion 20 (6): 479-484, 2002)Mutations at the myocflin (MYOC) gene within the GLC1A locus have been revealed in 2- 4% of patients suffering primary open angle glaucoma (POAG) worldwide. In our ongoing glaucoma study sixhundred eighty two persons ... -
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy
(2020)In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, ... -
Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: phylogenetic relationships and characterization of Clarkitoxin-I-Mdum
(2019)Micrurus mipartitus and M. dumerilii are the most medically important coral snakes in Colombia. Proteomic characterization of their venoms has previously shown that proteins of the three-finger toxin (3FTx) family ... -
Nueva estrategia didáctica y su evaluación por parte de los estudiantes del curso fisicoquímica farmacéutica
(2012-10)El curso de Fisicoquímica Farmacéutica II, que se imparte en la Facultad de Farmacia de la Universidad de Costa Rica, es uno de los más complicados para el desarrollo de los aprendizajes ... -
Nuevas terapias en hemofilia
(2021)La hemofilia es un desorden genético de herencia recesiva ligado al cromosoma X, la A se da por deficiencia del factor VIII mientras que la B por ausencia de IX. Se clasifican en tres grupos: leve, moderada y severa. Una ... -
Nuevos registros de Aedes albopictus (Skuse) en cuatro localidades de Costa Rica
(2017)Introducción. Aedes albopictus (Skuse) es un vector de arbovirus ampliamente distribuido. En Costa Rica, la expansión geográfica de Ae.albopictus se ha incrementado en la última década, por lo que es importante actualizar ... -
La nutrición en Costa Rica
(1991)El nuevo Hospital Nacional de Niños se había inaugurado cinco años atrás; sus flamantes instalaciones contrastaban con la incómoda construcción de madera del Hospital San Juan de Dios, nuestro Hospital General. No obstante ... -
Nutrient intake comparisons between Framingham and rural and urban Puriscal, Costa Rica: associations with Lipoproteins, apolipoproteins and low density lipoprotein particle size
(1991-07)To assess cross-cultural relations between dietary intake and plasma lipoproteins, we randomly selected 222 men and 243 women from the urban and rural areas of Puriscal, Costa Rica; related their dietary composition ... -
Nutrition and health in societies in transition
(In: Nutrition in Transition: Proceedings of the Western Hemisphere Nutrition Congress V, Quebec 1977, edited by Philip L. White and Nancy Selvey. (Chicago) American Medical Association, 1978, pp. 351-358, 1978-02-01)One often hears the expression that a country or society is "in transition," but there is not a clear definition of such, nor is there an effort to quantitate or characterize the level of transition undergone by a given ... -
Nutrition and infection
(Tropical and Geographical Medicine. New York: McGraw-Hill, pp. 206-211, 1984)The association of malnutrition and infectious disease (faminepestilence) had been recognized since the beginning of human history, but it was not until the late 1950s that such an interaction was scientifically documented ... -
Nutritional consequences of infection
(1986)This discussion will review current knowledge on malnutrition infection interactions, to provide a basis for justifiable interventions to curtail infectious diseases. Interventions should be implemented within the frame ... -
Nutritional lifestyle patterns and cancer: confounding effect of social determinants across the life course in women from the 1958 British birth cohort study
(2020)Objective: To examine the confounding role of social determinants across the life course in the relationship of nutritional lifestyle patterns with cancer in women. Methods: In the National Child Development Study, 37 ...