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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.
(2023)
Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of ...
Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
(2019)
The objective is to identify cofactors of leukocyte telomere length (LTL) in a Latin American population, specifically the association of LTL with 36 socio-demographic, early childhood, and health characteristics, as well ...
Differences in the association of cardiovascular risk factors with education: a comparison of Costa Rica (CRELES) and the USA (NHANES)
(J Epidemiol Community Health 2010; 64: 821-828, 2009-08-12)
Background Despite different levels of economic
development, Costa Rica and the USA have similar
mortalities among adults. However, in the USA there are
substantial differences in mortality by educational
attainment, ...
Life-course BMI and biomarkers in persons aged 60 years or older: a comparison of the USA and Costa Rica
(2019)
Objective: There is a large literature linking current body mass index (BMI) to levels of cardiovascular risk biomarkers, but it is unknown whether measures of BMI earlier in the life course and maximum BMI are predictive ...
Seasonal Variation of Peripheral Blood Leukocyte Telomere Length in Costa Rica: A Population-Based Observational Study
(2014)
ABSTRACT: Objectives: Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers ...
A cross-national comparison of 12 biomarkers finds no universal biomarkers of aging among individuals aged 60 and older
(2016)
There is uncertainty about whether biological and anthropometric measures that are
clinical risk factors for disease are universally associated with chronological age,
or whether these correlations vary depending on the ...
Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study
(2013)
Studies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica, known for exceptional longevity, had longer telomere ...
Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study
(2016-04)
Telomere length has generated substantial interest as a potential predictor of aging- related diseases and mortality. Some studies have reported significant associations, but few have tested its ability to discriminate ...
Epigenome-Wide Association Study and Epigenetic Age Acceleration Associated with Cigarette Smoking among Costa Rican Adults
(2022-03-11)
Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated ...
The Nicoya region of Costa Rica: A high longevity island for elderly males
(Vienna Yearbook of Population Research, Vol 11, 2013-11)
Reliable data show that the Nicoyan region of Costa Rica is a hot spot of high
longevity. A survival follow-up of 16,300 elderly Costa Ricans estimated a Nicoya
death rate ratio (DRR) for males 1990–2011 of 0.80 (0.69–0.93 ...