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Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae)
(2011-01-31)
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a “venomics” approach. Nearly 50 venom peaks were resolved by RP-HPLC, revealing a complex protein composition. Comparative ...
Venomics of new world pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon
(Journal of Proteomics vol 96, p.103-116, 2014-01-16)
Wereport a genus-wide comparison of venomproteomevariation acrossNewWorld pit vipers in the genus Agkistrodon. Despite the wide variety of habitats occupied by this genus and that all its taxa feed on diverse species of ...
Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom
(2008-10)
The venom proteomes of the snakes Bothrops caribbaeus and Bothrops lanceolatus, endemic to the
Lesser Antillean islands of Saint Lucia and Martinique, respectively, were characterized by reversephase
HPLC fractionation, ...
Omics Meets Biology: Application to the Design and Preclinical Assessment of Antivenoms
(Toxins vol.6:3388-3405, 2014-12-15)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact worldwide, mostly affecting poor people involved in agricultural activities in Africa, Asia, Latin America and Oceania. A ...
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
(2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...
Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis
(2008-04-30)
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America
(2010)
We report a comparative venomic and antivenomic characterization of the venoms of newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the subspecies cumanensis, durissus, ruruima, and ...
Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays
(En prensa, 2014-02-28)
Parenteral administration of animal-derived antivenoms constitutes the mainstay in the
treatment of snakebite envenomings. Despite the fact that this therapy has been available for over a century, the detailed understanding ...
Two color morphs of the pelagic yellow-bellied sea snake, pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom
(Journal of Proteomics Volume 103, 30 May 2014, Pages 137–152, 2014-05-30)
The yellow-bellied sea snake, Pelamis platura, is the most broadly distributed snake species. Despite being endowed with a highly lethal venom, a proteomic analysis of its toxin composition was unavailable. The venoms of ...
First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis
(Toxicon vol 93:144–154, 2015-01)
Bothriechis nigroviridis is an arboreal Neotropical pitviper found in Costa Rica and Panam a. A previous
proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits
of ...