Listar Microbiología por autor "da5588a3-b985-4ce7-8cf5-240c93f9f35f"
Mostrando ítems 1-2 de 2
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A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation
Acón, Man Sai; Siles Canales, Francisco; Mora Rodríguez, Rodrigo Antonio (2016-11-09)Cancer complexity and resistance is mediated by cell-to-cell heterogeneity, which is the consequence of the enormous instability of its genetic material. It is unknown how cancer cells are able to withstand the effects ... -
MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
Acón, Man Sai; Geiß, Carsten; Torres Calvo, Jorge; Bravo Estupiñan, Diana; Oviedo Blanco, Guillermo; Arias Arias, Jorge Luis; Rojas Matey, Luis Andres; Báez Villalobos, Edwin; Vásquez Vargas, Gloriana; Oses Vargas, Yendry; Guevara Coto, José Andrés; Segura Castillo, Andrés; Siles Canales, Francisco; Quirós Barrantes, Steve; Régnier Vigouroux, Anne; Mendes, Pedro; Mora Rodríguez, Rodrigo Antonio (2021-12-17)We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics ...