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Gene Expression Dynamics Induced by Ciprofloxacin and Loss of LexA Function in Pseudomonas aeruginosa PAO1 Using Data Mining and Network Analysis
(2018)
Pseudomonas aeruginosa is an opportunistic
pathogen that causes a variety of infections in humans and
frequently develops mechanisms of resistance to antibiotics, which
makes its treatment difficult. In this study we ...
SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation
(2021)
Genome sequencing is a key strategy in the surveillance of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Latin America is the hardest-hit region of the world, accumulating almost 20% of COVID-19 cases ...
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
(2021)
Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2
virus, define a large spectrum of symptoms that are mainly dependent on the human host
conditions. In Costa Rica, almost 319 000 cases ...
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Bioinformatics advances in Costa Rica: Retrospective view and perspectives
(2021-11-09)
Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ...
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
(2018)
Cancer is a group of heterogeneous and complex
diseases, with limited therapeutic options due to the recurrent
emergence of drug resistance. Sphingolipids are bioactive
molecules that participate in signaling of cell ...
Two-dimensional gel electrophoresis image analysis of two Pseudomonas aeruginosa clones
Análisis de imágenes bidimensionales de electroforesis en gel de dos clones de Pseudomonas aeruginosa
(2022-11-17)
A classical strategy to analyse the protein content of a biological sample is the two-dimensional
gel electrophoresis (2D-GE). This technique separates proteins by both isoelectric point and
molecular weight, and images ...
Elucidating Spirocerca lupi spread in the Americas by using phylogenetic and phylogeographic analyses
(2023)
Spirocerca lupi is a parasitic nematode of domestic and wild canids of the world. This nematode induces esophageal spirocercosis and may eventually lead to carcinomas, aortic aneurisms, and death of the animal. Two genotypes ...
Metagenomic pipeline for identifying co-infections among distinct SARS-CoV-2 variants of concern: Study cases from Alpha to Omicron
(2022)
Concomitant infection or co-infection with distinct SARS-CoV-2 genotypes have been reported as part of
the epidemiological surveillance of the COVID-19 pandemic. In the context of the spread of more
transmissible variants ...
Transcriptomic determinants of the response of ST-111 Pseudomonas aeruginosa AG1 to ciprofloxacin identified by a top-down systems biology approach
(2020)
Pseudomonas aeruginosa is an opportunistic pathogen that thrives in diverse environments and causes a variety of human infections. Pseudomonas aeruginosa AG1 (PaeAG1) is a high-risk sequence type 111 (ST-111) strain isolated ...