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Naphthalenones and Isocoumarins from a Costa Rican Fungus Xylariaceae sp. CR1546C
(2014)
A new naphthalenone, (R)-4,6,8-trihydroxy-3,4-dihydro-1(2H)-naphthalenone and a new isocoumarin, 6,8-dihydroxy-(3R)-(2-oxopropyl)-3,4-dihydroisocoumarin, together with eight related known compounds were isolated from the ...
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
(2013)
Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell ...
Identification of Protein Kinase C Activation as a Novel Mechanism for RGS2 Protein Upregulation through Phenotypic Screening of Natural Product Extracts
(2014)
Biochemical high-throughput screening is widely used in drug discovery, using a variety of small molecule libraries. However, broader screening strategies may be more beneficial to identify novel biologic mechanisms. In ...
Phenolic compounds as antiangiogenic CMG2 inhibitors from costa rican endophytic fungi
(2012)
Targeting and inhibiting CMG2 (Capillary Morphogenesis Gene protein 2) represents a new strategy for therapeutic agents for cancer and retinal diseases due to CMG2’s role in blood vessel growth (angiogenesis). A high ...