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Cyclin-dependent kinase 4/6 inhibitors as first-line treatment for post-menopausal metastatic hormone receptor-positive breast cancer patients: a systematic review and meta-analysis of phase III randomized clinical trials.
(2018)
Background
To compare the efficacy and toxicity of the combination of cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors and nonsteroidal aromatase inhibitors (AI) versus AI alone as first-line therapy for patients with ...
Physiological wear-and-tear and later subjective health in mid-life: Findings from the 1958 British birth cohort
(2016)
Our body adapts continuously to environmental challenges and stressful conditions. Allostatic load (AL) is a concept that aims to capture the overall physiological wear-and-tear of the body triggered by the repeated ...
Patient Organizations’ Barriers in Pharmacovigilance and Strategies to Stimulate Their Participation
(2020)
European drug regulations aim for a patient-centered approach, including involving patients in the pharmacovigilance (PV) systems. However many patient organizations have little experience on how they can participate in ...
High 18:2 trans fatty acids are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults
(2003)
Trans-fatty acid intake is associated with coronary heart disease (CHD), but the atherogenic potential of individual trans-fatty acids (FA) from partially hydrogenated oils (18:1 and 18:2) or meat and dairy products (16:1 ...
De la influenza pandémica a la COVID-19: Un siglo después, ¿se repite la historia?
From pandemic influenza to COVID-19: A century later, history repeating itself?
(2021)
Actualmente, el mundo se enfrenta a la pandemia de la COVID-19. Su magnitud es comparable a la pandemia por influenza de 1918. En la pandemia de 1918, condiciones de tipo socioeconómicas, demográficas y culturales fueron ...
Venom diversity in the neotropical genus Tityus: implications for antivenom design emerging from molecular and immunochemical analyses across endemic areas of scorpionism
(2020)
Scorpions of the Neotropical genus Tityus are responsible for most severe envenomations in the Caribbean, South America, and Lower Central America (LCA). Although Tityus is taxonomically complex, contains high toxin ...
The Type of Oil Used for Cooking Is Associated with the Risk of Nonfatal Acute Myocardial Infarction in Costa Rica
(2005)
Palm oil and soybean oil are the 2 most widely used cooking oils in the world. Palm oil is consumed mainly in developing countries, where morbidity and mortality due to cardiovascular disease (CVD) are on the rise. Although ...
Crystallographic and Topographic Analysis of Ultra-Translucent Zirconia After Various Surface Treatments
Análisis cristalográfico y topográfico de la zirconia ultra-translúcida después de diversos tratamientos de superficie
(2024-03-07)
The aim of the present study was to analyze the effects of 4 different surface treatments, on the crystallographic characteristics of Ultra-Translucent Zirconia. Fully sintered zirconia specimens of highly translucent ...
Vector-borne pathogens in dogs from Costa Rica: First molecular description of Babesia vogeli and Hepatozoon canis infections with a high prevalence of monocytic ehrlichiosis and the manifestations of co-infection
(2014)
Infection with canine vector-borne pathogens was evaluated in dogs from four different
regions of Costa Rica by PCR. Demographic data, clinical signs, packed cell volume values,
and the presence of tick infestation were ...
Detection of Dirofilaria immitis and other arthropod-borne filarioids by an HRM real-time qPCR, blood-concentrating techniques and a serological assay in dogs from Costa Rica
(2015)
Background: Canine filarioids are important nematodes transmitted to dogs by arthropods. Diagnosis of canine
filariosis is accomplished by the microscopic identification of microfilariae, serology or PCR for filarial-DNA. ...