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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.
(2023)
Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of ...
Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
(2019)
The objective is to identify cofactors of leukocyte telomere length (LTL) in a Latin American population, specifically the association of LTL with 36 socio-demographic, early childhood, and health characteristics, as well ...
The vanishing advantage of longevity in Nicoya, Costa Rica: A cohort shif
(2023)
BACKGROUND
The Nicoya region in Costa Rica has been identified as one of a handful of hotspots of
extreme longevity. The evidence supporting this status comes mostly from observing the
1990 and 2000 decades and cohorts ...
Life-course BMI and biomarkers in persons aged 60 years or older: a comparison of the USA and Costa Rica
(2019)
Objective: There is a large literature linking current body mass index (BMI) to levels of cardiovascular risk biomarkers, but it is unknown whether measures of BMI earlier in the life course and maximum BMI are predictive ...
Estacionalidad de la mortalidad en los trópicos. El caso de Costa Rica, 1970-2016
Seasonal Variation of Mortality in the Tropics. The Case of Costa Rica, 1970-2016
(2019)
El objetivo de esta investigación es determinar la existencia y magnitud de ciclos de variación estacional en la mortalidad de Costa Rica de 1970 a 2016. Metodológicamente, el estudio se basa en microdatos de 630,000 ...