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DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria
(2019)
Mutations in DNA repair enzymes can cause two neurological clinical manifestations: a developmental impairment and a degenerative disease. Polynucleotide kinase 3′-phosphatase (PNKP) is an enzyme that is actively involved ...
Contaminación del agua del río Durazno, Costa Rica: más allá del índice holandés de calidad del agua
Pollution of the Durazno River water, Costa Rica: beyond the Dutch water quality index
(2023-06-01)
Introduction: The micro-basin of the Durazno River in Costa Rica is a source of water for human consumption, but is suspected of microbiological pollution from several land uses. Objective: To assess the water quality of ...
Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents
(2019-01)
Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized
and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds
were also evaluated. The ...
Evaluación de la influencia de la estacionalidad climática en calidad del agua de consumo humano en un sistema de abastecimiento en San José, costa rica, periodo 2017-2018
Evaluation of climatic seasonal influence on the quality of water for human consumption in a San José (Costa Rica) supply system, 2017-2018
(2019)
Objetivo: Analizar el estado y la influencia de la variabilidad climática en la calidad del agua de un sistema de abastecimiento para consumo humano en San José, Costa Rica, captado en cuatro microcuencas del cantón Vásquez ...
Menopause, A Universal Female Experience: Lessons from Mexico and Central America
(Current Women’s Health Reviews 4(1), 3-8, 2008)
In Mexico and Central America, women typically experience menopause up to 10 years earlier than their U.S. counterparts. This may be due in part to numerous pregnancies, long periods of lactation, poor nutrition, extreme ...
Gene Expression Dynamics Induced by Ciprofloxacin and Loss of LexA Function in Pseudomonas aeruginosa PAO1 Using Data Mining and Network Analysis
(2018)
Pseudomonas aeruginosa is an opportunistic
pathogen that causes a variety of infections in humans and
frequently develops mechanisms of resistance to antibiotics, which
makes its treatment difficult. In this study we ...
Women’s participation in pap smear screening in a developing country: evidence for improving health systems
(2021-06-15)
Introduction: Every year about 83,000 women are diagnosed with cervical cancer in the Americas. Latin America and the Caribbean (LAC) has one of the highest incidence and mortality rates from cervical cancer in the world. ...
Factores relacionados con resultados negativos asociados a la medicación en enfermedades infecciosas. Estudio exploratorio
(2023)
Objetivo. Analizar factores relacionados con resultados negativos asociados a la medicación en enfermedades infecciosas, a partir del servicio de seguimiento farmacoterapéutico, que permita tener un perfil de estos.
Método. ...
Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort
(2015)
Allostatic load (AL) is a measure of overall physiological wear-and-tear over the life course, which could partially be the consequence of early life exposures. AL could allow a better understanding of the potential ...
Components of the metabolic syndrome among a sample of overweight and obese Costa Rican schoolchildren
(2009)
Background. The term “pediatric metabolic syndrome” includes a cluster of cardiovascular risk factors such as insulin resistance, dyslipidemia (including increased triglycerides and decreased HDL cholesterol), hypertension, ...