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Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico
(2013-08-01)
The rock rattlesnakes Crotalus lepidus comprise a group (lepidus, klauberi, morulus and
maculosus) of poorly known mountain cold-tolerant snakes in Mexico. In particular, Crotalus
lepidus morulus is a snake endemic of ...
Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms
(2021)
Snakebite envenoming is an important occupational health problem, particularly in rural areas of developing countries. The timely administration of an effective antivenom remains the mainstay of snakebite management. ...
Identification of linear B-cell epitopes on myotoxin-II, a Lys49 phospholipase A2 homologue from Bothrops asper snake venom
(2012)
Knowledge on toxin immunogenicity at the molecular level can provide valuable information
for the improvement of antivenoms, as well as for understanding toxin structure–
function relationships. The aims of this study ...
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)
(1987)
Neutralization of biological activities of B. asper myotoxin by a monospecific anti-myotoxin rabbit serum and polyvalent antivenom was studied. Both antisera neutralized myotoxic, phospholipase A and lethal activities of ...
Snake Venomics of Central American Pitvipers: Clues for Rationalizing the Distinct Envenomation Profiles of Atropoides nummifer and Atropoides picadoi
(2008)
We report the proteomic characterization of the Central American pitvipers Atropoides nummifer and
Atropoides picadoi. The crude venoms were fractionated by reverse-phase high-performance liquid
chromatography (HPLC), ...
Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro
(2006-07)
Previous studies have shown that calcineurin activity plays a critical role in the myotoxic activity induced by crotoxin (CTX), a group II phospholipase A2 (PLA2) with neurotoxic and myotoxic actions. In order to address ...
Las citokinas, elementos centrales para la comprensión y manipulación terapéutica del sistema inmune (Parte 1)
(1995)
Dentro del explosivo desarrollo en que se encuentra la inmunología básica, el campo de las citokinas y sus funciones dentro (y fuera) del sistema inmune, es uno de los que crece más vertiginosamente. En la primera parte ...
Crystallization of the Lys49 PLA2 homologue, myotoxin II from the venom of Atropoides nummifer
(2004-12)
Myotoxin II, a Lys49 catalytically inactive phospholipase A2 homologue from Atropoides nummifer venom, was purified, characterized
and crystallized. The crystals belongs to the tetragonal system, space group P43212, with ...
Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia
(1982)
The neutralizing capacity of the blood serum of the non-venomous snake Clelia clelia against the hemorrhagic, edematous and myonecrotic effects of Bothrops asper venom in white mice was tested using in vitro preincubation ...
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice
(1996)
The ability of pre-existing antibodies to neutralize locally-acting toxins of Bothrops
asper snake venom was investigated. Hemorrhage, myonecrosis, and edema
were markedly reduced in actively immunized mice, although ...