Micronuclei frequency in lymphocytes of individuals occupationally exposed to pesticides
artículo original
Date
2001Author
Ramírez Mayorga, Vanessa
Cuenca Berger, Patricia
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Show full item recordAbstract
Pesticides have been widely used in developing countries over the years. A large amount of these
remains in the environment and organisms. Pesticide pollution is detrimental to human health. The effects can
be seen on a short or a long-term basis and the symptoms can vary from headache to cancer. Only a minority
of studies focuses on their genotoxic effect. This study assesses the genotoxic effect of the pesticides used at
banana-packaging plants with binucleate micronuclei assay using cultured lymphocytes. The studied population
included 32 exposed and 37 unexposed women from Costa Rica. There is no significant difference between
the two groups. However, women who worked at the packaging plant and had stillbirths or spontaneous abortions
were 1.45 times more (a = 0.06) likely to have an increased micronuclei frequency than their coworkers
who lacked those disorders; this may indicate genetic susceptibility. In vitro pesticides studies and susceptibility
biomarkers are needed to identify subgroups with higher risks.
Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2001
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