Buscar
Mostrando ítems 11-20 de 47
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
(2019)
Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death
by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes
are ...
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
(2021-09)
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle ...
Enzymatic labelling of venom phospholipase A2 toxins
(2019)
Almost all animal venoms contain secretory phospholipases A2 (PLA2s), 14 kDa disulfide-rich enzymes that
hydrolyze membrane phospholipids at the sn-2 position, releasing lysophospholipids and fatty acids. These
proteins, ...
Snake venomics, experimental toxic activities and clinical characteristics of human envenomation by Bothrocophias myersi (Serpentes: Viperidae) from Colombia
(2020)
Venoms of the viperid genus Bothrocophias, restricted to Colombia and Ecuador, are poorly known. Only a proteomic analysis of B. campbelli venom has been described. In this work we present a proteomic study of B. myersi ...
First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis
(Toxicon vol 93:144–154, 2015-01)
Bothriechis nigroviridis is an arboreal Neotropical pitviper found in Costa Rica and Panam a. A previous
proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits
of ...
Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A2 ex vivo does not involve a direct action on the contractile apparatus
(2023)
Myonecrosis is a frequent clinical manifestation of envenomings by Viperidae snakes, mainly caused by the toxic actions of
secreted phospholipase A2
(
sPLA2) enzymes and sPLA2-
like homologs on skeletal muscle fibers. ...
Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo
(PLoS One 9(10):e109846, 2014-10-07)
Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis, ‘Asp49’ and ‘Lys49’ myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic activity, two different mechanisms are ...
An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity
(2020)
Snakebite envenoming is a major neglected tropical disease that affects millions of people every year. The only effective treatment against snakebite envenoming consists of unspecified cocktails of polyclonal antibodies ...
Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity
(2018)
Phospholipases A2 are a major component of snake venoms. Some of them cause severe muscle necrosis
through an unknown mechanism. Phospholipid hydrolysis is a possible explanation of their toxic action,
but catalytic and ...
A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling
(Cell Death and Disease (2012) 3, e343, 2012-07-05)
Lys49-PLA2 myotoxins, an important component of various viperid snake venoms, are a class of PLA2-homolog proteins deprived of catalytic activity. Similar to enzymatically active PLA2 (Asp49) and to other classes of ...