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Ent-clerodane derivatives and other constituents from representatives of the subgenus ageratina
(1989)
Ageratina ixiocladon afforded several p-hydroxyacetophenone derivatives and diterpenes including six new ent-clerodanes. Two further species, which are also placed in the subgenus Ageratina, gave p-hydroxyacetophenone ...
Separation of crude plant extracts with high speed CCC for primary screening in drug discovery
(2001)
High speed countercurrent chromatography (HSCCC) was used
in a pre-fractionation pilot study to improve the quality of crude
plant samples for primary screening in drug discovery efforts. The
methanol ...
Identification of polyphenols from antiviral Chamaecrista nictitans extract using high-resolution LC–ESI–MS/MS
(2014)
Chamaecrista nictitans (L) extract possesses antiviral properties; it acts against the herpes simplex virus, and this may be attributed to its constituent phenolics. Here, high-resolution LC–ESI–MS/MS is used to identify ...
The Combined Use of Alphavirus Replicons and Pseudoinfectious Particles for the Discovery of Antivirals Derived from Natural Products
(2015)
Alphaviruses are a prominent class of reemergent pathogens due to their globally expanding ranges, potential for lethality, and possible use as bioweapons. The absence of effective treatments for alphaviruses highlights ...
Inhibition of granulocyte elastase activity by caffeic acid derivatives
(1999)
In former studies it was shown that bornyl derivates may contribute to the anti-inflamatory activity of some drugs, such as Verbesia turbacensis, Notopterygium incisum or Coreopsis mutica.
Unusual Microbial Xylanases from Insect Guts
(2004-06-07)
Recombinant DNA technologies enable the direct isolation and expression of novel genes from biotopes containing complex consortia of uncultured microorganisms. In this study, genomic libraries were constructed from microbial ...
Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae
(1998)
The isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported.
The first potent and selective ...
Diterpenes and sesquitrpenes from Mikania banisteriae
(1997)
Two new ent-kaurane diterpenes, 18,19-diacetoxy-ent-kaur-16-ene and 17-oxo-ent-kaur-15(16)-en-18-oic acid, were isolated from the aerial parts of Mikania banisteriae, together with the known ent-kauranes ent-kaur-16-en-18-oic ...
Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
(2013)
Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell ...
Screening of Latin American Plants for Cytotoxic Activity
(2006)
The SRB cytotoxicity assay was used to screen plant extracts, in a collaborative multinational OAS project involving Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, against breast (MCF-7), lung ...