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dc.creatorFernández Ulate, Julián
dc.creatorVargas Vargas, Nancy
dc.creatorPla Ferrer, Davinia
dc.creatorSasa Marín, Mahmood
dc.creatorRey Suárez, Paola
dc.creatorSanz, Libia
dc.creatorGutiérrez, José María
dc.creatorCalvete Chornet, Juan José
dc.creatorLomonte, Bruno
dc.date.accessioned2017-07-04T21:40:18Z
dc.date.available2017-07-04T21:40:18Z
dc.date.issued2015-12-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010115300465es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/30181
dc.description.abstractProtein composition, toxicity, and neutralization of the venoms of Micrurus alleni and Micrurus mosquitensis, two sympatric monadal coral snakes found in humid environments of the Caribbean region of Costa Rica, were studied. Proteomic profiling revealed that these venoms display highly divergent compositions: the former dominated by three-finger toxins (3FTx) and the latter by phospholipases A2 (PLA2). Protein family abundances correlated with enzymatic and toxic characteristics of the venoms. Selective inhibition experiments showed that PLA2s play only a marginal role in the lethal effect of M. alleni venom, but have a major role in M. mosquitensis venom. Proteomic data gathered from other Micrurus species evidenced that the two divergent venom phenotypes are recurrent, and may constitute a general trend across New World elapids. Further, M. mosquitensis, but not M. alleni, venom contains PLA2-like/Kunitz-type inhibitor complex(es) that resemble the ASIC1a/2-activating MitTx heterodimeric toxin isolated from Micrurus tener venom. The evolutionary origin and adaptive relevance of the puzzling phenotypic variability of Micrurus venoms remain to be understood. An antivenom against the PLA2-predominant Micrurus nigrocinctus venom strongly cross-recognized and neutralized M. mosquitensis venom, but only weakly M. alleni venom.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B3-760]/UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Economía y Competitividad/[BFU2013-42833-P]//Españaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 107, Parte B. 2015es_ES
dc.subjectCoral snakees_ES
dc.subjectVenomes_ES
dc.subjectElapidaees_ES
dc.subjectMicrurus allenies_ES
dc.subjectMicrurus mosquitensises_ES
dc.subjectAntivenomes_ES
dc.titleSnake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapidses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2015.08.016
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid26325292


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