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dc.creatorQuirós Fallas, María isabel
dc.creatorVargas Huertas, Felipe
dc.creatorQuesada Mora, Silvia
dc.creatorAzofeifa Cordero, Gabriela
dc.creatorWilhelm Romero, Krissia
dc.creatorVásquez Castro, Felipe
dc.creatorAlvarado Corella, Luis Diego
dc.creatorSánchez Kopper, Andrés
dc.creatorNavarro Hoyos, Mirtha
dc.date.accessioned2022-03-11T16:06:52Z
dc.date.available2022-03-11T16:06:52Z
dc.date.issued2022-03
dc.identifier.citationhttps://www.mdpi.com/journal/antioxidantses_ES
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/10669/86030
dc.description.abstractCurcuma longa constitutes an important source of secondary metabolites that have been associated with multiple health benefits. For instance, curcumin, demethoxycurcumin and bisdemethoxy-curcumin, have been found to perform important biological activities, such as anti-inflammatory, antioxidant, anticancer, antimicrobial, antihypertensive and anticoagulant. These promising results prompted this research to evaluate the polyphenols of C. longa rhizomes in Costa Rica. The present work reports a comprehensive study on the polyphenolic profile and the contents of the three main curcuminoids as well as the antioxidant activity of extracts from C. longa rhizomes (n = 12) produced in Costa Rica. Through UPLC-QTOF-ESI MS, a total of 33 polyphenols were identified, grouped in eight types of structures. In addition, our findings on the main curcuminoids using UPLC-DAD show all rhizomes complying with total curcuminoids (TC) content established by the United States Pharmacopeia (USP). At individual level, samples NW-3 and NE-1 show the higher contents (118.7 and 125.0 mg/g dry material), representing more than twice the average values of the lowest samples. These samples also exhibit the highest Folin-Ciocalteu (FC) reducing capacity results as well as the best DPPH (IC50 15.21 and 16.07 µg extract/mL) and NO (IC50 between 52.5 and 54.3 µg extract/mL) antioxidant values. Further, Pearson correlation analysis findings indicated positive correlation (p < 0.05) between TC, CUR with FC results (r = 0.833 and r = 0.867 respectively) and negative correlation (p < 0.05) between CUR, TC and FC with DPPH results (r = -0.898, r = -0.911, and r = -0.890, respectively) and between NO results and DPPH (r = -0.805, p < 0.05). Finally, results for Principal Component Analysis (PCA) showed composition variability associated with their re-gion of origin with products from the Northeastern (NE) region exhibiting higher average values for FC, TC and antioxidant activities. Further, PCA confirmed that two samples, namely NE-1 and NW-3 stand out by presenting the highest PC1 due to their particularly high TC, CUR and anti-oxidant activities. Consequently, our findings agree with previous results indicating the importance of C. longa extracts to elaborate products with potential benefits for health, while delivering extracts with higher levels of curcuminoids than previous reports and exhibiting high antioxidant activity.es_ES
dc.language.isoenges_ES
dc.sourceAntioxidants (accepted)es_ES
dc.subjectCurcuma longaes_ES
dc.subjectcurcumines_ES
dc.subjectdemethoxycurcumines_ES
dc.subjectbisdemethoxycurcumines_ES
dc.subjectpolyphenolses_ES
dc.subjectQTOF-ESI MSes_ES
dc.titlePolyphenolic HRMS Characterization, Contents and Antioxidant Activity of Curcuma longa rhizomes from Costa Ricaes_ES
dc.typeartículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.identifier.codproyecto115-B8-150
dc.identifier.codproyecto115-C0-001
dc.identifier.codproyecto115-C1-501


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