Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

artículo científico
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Fecha
1998
Autor
Goetz, Michael A.
Hensens, Otto D.
Zink, Deborah L.
Borris, Robert P.
Morales Quirós, Juan Francisco
Tamayo Castillo, Giselle
Slaughter, Robert S.
Felix, John P.
Ball, Richard G.
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Resumen
The isolation and structure elucidation of two novel nor-triterpenoid KV1.3 potassium channel blockers correolide and dehydrocorreolide from the Costa Rican tree Spachea correae are reported. The first potent and selective small molecule blockers of KV 1.3, cprreolide (1) and its dehydro derivative 2 have been identified from extracts of Spachea correoe. Agents that inhibit the opening of this voltage-gated potassium channel can be expected to have immunosuppressive properties.
URI
https://hdl.handle.net/10669/87847
External link to the item
10.1016/S0040-4039(98)00427-4
https://www.sciencedirect.com/science/article/pii/S0040403998004274#!
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