Synthesis of 2-hydroxy-3-substituted naphthoquinones using the Heck reaction
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Authors
Pérez Sánchez, Alice Lorena
Lamoureux Lamontagne, Guy
Zhen-Wu, Bi Yun
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Abstract
An efficient Heck coupling of 2-hydroxy-3-iodo-naphthoquinone with a series of electron-deficient alkenes in aqueous solution has been accomplished. The method is characterized by simple conditions and facile work-up to isolate the products in good to excellent yields. The products contain the motif present in several naphthoquinone pigments but with enhanced polarity.
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Keywords
Heck reaction, Hooker condensation, Naphthoquinone, 2-Hydroxy-3-iodonaphthoquinone
Citation
http://www.sciencedirect.com/science/article/pii/S0040403907006922