Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice
dc.creator | Chaves Mora, Fernando | |
dc.creator | Teixeira, Catarina de Fátima | |
dc.creator | Gutiérrez, José María | |
dc.date.accessioned | 2017-01-18T20:42:30Z | |
dc.date.available | 2017-01-18T20:42:30Z | |
dc.date.issued | 2005-02 | |
dc.description.abstract | The role of the cytokines TNF-α, IL-1β and IL-6 in the acute local pathological effects induced by Bothrops asper snake venom was assessed in mice. Intramuscular injection of this venom induced increments in IL-1β and IL-6 in muscle, but no elevations of TNF-α were detected. Pentoxifylline (PTX), a methylxanthine derivative that inhibits the synthesis of TNF-α, and antibodies against these three cytokines were used to assess the role of these cytokines in venom-induced effects. As a control, PTX pretreatment was effective at abrogating lethality and serum TNF-α increments in mice subjected to endotoxemia induced by injection of Escherichia coli lipopolysaccharide, although it did not affect the increment in IL-1β and IL-6 in such endotoxic model. PTX failed to reduce lethality, hemorrhage, myonecrosis, dermonecrosis and edema induced by B. asper venom. Moreover, pretreatment with anti-cytokine antibodies was also ineffective at reducing venom-induced myonecrosis and hemorrhage. It is concluded that TNF-α, IL-1β and IL-6 do not have a significant role in the pathogenesis of the acute local pathological effects induced by B. asper venom in mice, although this does not exclude the possibility that these cytokines play a role in other aspects of venom-induced local pathology, as well as in the reparative and regenerative responses that take place after the onset of tissue damage. | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.description.sponsorship | Universidad de Costa Rica/[741-A3-025]/UCR/Costa Rica | es_ES |
dc.description.sponsorship | United Nations Educational, Scientific and Cultural Organization/[883.701-3]/UNESCO/ | es_ES |
dc.identifier.citation | http://www.sciencedirect.com/science/article/pii/S0041010104004209 | |
dc.identifier.codproyecto | 741-A3-025 | |
dc.identifier.doi | https://doi.org/10.1016/j.toxicon.2004.10.005 | |
dc.identifier.issn | 0041-0101 | |
dc.identifier.uri | https://hdl.handle.net/10669/29438 | |
dc.language.iso | en_US | es_ES |
dc.rights | acceso embargado | |
dc.source | Toxicon; Volumen 45, Número 2, 2005 | es_ES |
dc.subject | Bothrops Asper Venom | es_ES |
dc.subject | TNF-α | es_ES |
dc.subject | IL-1β | es_ES |
dc.subject | IL-6 | es_ES |
dc.subject | Pentoxifylline | es_ES |
dc.subject | Myonecrosis | es_ES |
dc.subject | Hemorrhage | es_ES |
dc.subject | Snake venom | es_ES |
dc.title | Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice | es_ES |
dc.type | artículo original |
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