(1S,3R)-N-{(3S,10S,12S,13R,17R)-12-Hydroxy-17- [(R)-5-hydroxypentan-2-yl]-10,13-dimethylhexa- decahydro-1H-cyclopenta[a]phenanthren-3-yl}- adamantane-1-carboxamide 0.25-hydrate
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Fecha
2022-10-12
Tipo
artículo original
Autores
Campos Fernández, Cristian Saúl
Procúpez Schtirbu, Rolando
Soto Tellini, Victor Hugo
Salazar Camacho, Juan Carlos
Jancik, Vojtech
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Resumen
The title compound, C 35H 57 NO 3 0.25H 2O, was synthesized from deoxycholic
acid followed by a protection, a Mitsonobu substitution, a Staudinger reduction,
formation of an amide and final reduction in the lateral chain. The compound
crystallizes in the P1 space group with four steroid molecules and one water
molecule in the triclinic cell unit. The crystal structure features O—H O
hydrogen bonding. The crystal studied was refined as a non-merohedral twin
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Palabras clave
Química Cristalografía, biological activity, crystal structure, bile salts