(1S,3R)-N-{(3S,10S,12S,13R,17R)-12-Hydroxy-17- [(R)-5-hydroxypentan-2-yl]-10,13-dimethylhexa- decahydro-1H-cyclopenta[a]phenanthren-3-yl}- adamantane-1-carboxamide 0.25-hydrate

Campos Fernández, Cristian Saúl; Procúpez Schtirbu, Rolando; Soto Tellini, Victor Hugo; Salazar Camacho, Juan Carlos; Jancik, Vojtech

(1S,3R)-N-{(3S,10S,12S,13R,17R)-12-Hydroxy-17- [(R)-5-hydroxypentan-2-yl]-10,13-dimethylhexa- decahydro-1H-cyclopenta[a]phenanthren-3-yl}- adamantane-1-carboxamide 0.25-hydrate

Archivos

bt4124 print.pdf (437.25 KB)

Fecha

2022-10-12

Tipo

artículo original

Autores

Campos Fernández, Cristian Saúl

Procúpez Schtirbu, Rolando

Soto Tellini, Victor Hugo

Salazar Camacho, Juan Carlos

Jancik, Vojtech

Resumen

The title compound, C 35H 57 NO 3 0.25H 2O, was synthesized from deoxycholic acid followed by a protection, a Mitsonobu substitution, a Staudinger reduction, formation of an amide and final reduction in the lateral chain. The compound crystallizes in the P1 space group with four steroid molecules and one water molecule in the triclinic cell unit. The crystal structure features O—H O hydrogen bonding. The crystal studied was refined as a non-merohedral twin