Biodegradation of Pharmaceuticals by Fungi and Metabolites Identification
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Fecha
2012-01-01
Tipo
capítulo de libro
Autores
Cruz Morató, Carles
Rodríguez Rodríguez, Carlos E.
Marco Urrea, Ernest
Sarrà Adroguer, Montserrat
Caminal, Glòria
Vicent, Teresa
Jelić, Aleksandra
García Galán, María Jesús
Pérez Solsona, Sandra
Díaz Cruz, M. Silvia
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Resumen
Pharmaceutical compounds comprise a widely employed group of
therapeutic agents now considered as emerging micropollutants. This chapter
summarizes the state of the art in the degradation of pharmaceuticals by fungi in
liquid matrices (with emphasis on white-rot fungi), including the use of both whole
cells and fungal enzymes. The identification of the metabolites produced as well
as the proposed degradation pathways available for some drugs are discussed.
The information is organized according to the activity of the pharmaceutical
compounds, grouped in: anti-inflammatory/analgesic drugs, psychiatric drugs,
lipid regulators, antibiotics and other antimicrobial agents, b-blockers, estrogens,
and iodinated contrast media. Considering the interest in potential application of
fungal treatments in future real scale bioremediation of effluents, the ecotoxicology
of the process is included when available.
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Palabras clave
Degradation, PHARMACEUTICALS, TOXICOLOGY, Trasnformation products, White-rot fungi