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Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom

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dc.creatorMurakami, Mário T.
dc.creatorMelo, Cristiane C.
dc.creatorAngulo Ugalde, Yamileth
dc.creatorLomonte, Bruno
dc.creatorArni, Raghuvir K.
dc.date.accessioned2018-02-26T21:26:31Z
dc.date.available2018-02-26T21:26:31Z
dc.date.issued2006
dc.description.abstractLys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 A ° resolution and the anion-binding site has been characterized.es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología/[FV-058-02]/CONICIT/Costa Ricaes_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo/[]/FAPESP/Brasiles_ES
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico/[]/CNPq/Brasiles_ES
dc.identifier.citationhttp://scripts.iucr.org/cgi-bin/paper?S1744309106010700
dc.identifier.doi10.1107/S1744309106010700
dc.identifier.issn1744-3091
dc.identifier.urihttps://hdl.handle.net/10669/74162
dc.language.isoen_USes_ES
dc.rightsacceso abierto
dc.sourceActa Crystallographica F 62, 423-426 (2006)es_ES
dc.subjectmyotoxines_ES
dc.subjectSnake venomes_ES
dc.subjectLys49 phospholipase A2es_ES
dc.subjectanion-binding siteses_ES
dc.titleStructure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venomes_ES
dc.typeartículo original

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