Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae)
| dc.creator | Steinbrueck, Clara | |
| dc.creator | Mora Ugalde, Nohelia | |
| dc.creator | Morales Sánchez, Carlos | |
| dc.creator | Loaiza Montoya, Randall | |
| dc.creator | García Piñeres, Alfonso J. | |
| dc.creator | Araya Barrantes, Juan José | |
| dc.date.accessioned | 2019-08-14T19:12:35Z | |
| dc.date.available | 2019-08-14T19:12:35Z | |
| dc.date.issued | 2019 | |
| dc.date.updated | 2019-08-06T16:38:55Z | |
| dc.description.abstract | Bioassay-guided fractionation of Acnistus arborescens (Solanaceae) organic extract afforded two anti-inflammatory withanolides: 2,3-Dihydro-3β-O-sulfate withacnistin (1) and 2,3-Dihydro-3β-O-sulfate withaferin A (2) showing IC50 values of 1.0 ± 0.1 and 14 ± 1 μM respectively in a LPS-stimulated RAW 264.7 murine macrophage assay. These compounds were also evaluated against two selected cancer cell lines showing significant cytotoxicity. Although there are several reports dealing with the chemistry of this species, we report for the first time the isolation of O-sulfated withanolides. | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biología | es_ES |
| dc.description.sponsorship | Universidad de Costa Rica/[ 801-B8-511]/UCR/Costa Rica | es_ES |
| dc.identifier.citation | https://www.sciencedirect.com/science/article/pii/S1874390018302556#! | |
| dc.identifier.codproyecto | 801-B8-511 | |
| dc.identifier.doi | 10.1016/j.phytol.2018.12.001 | |
| dc.identifier.issn | 1874-3900 | |
| dc.identifier.uri | https://hdl.handle.net/10669/78890 | |
| dc.language.iso | en_US | es_ES |
| dc.relation.ispartof | ||
| dc.rights | acceso embargado | |
| dc.source | Phytochemistry Letters, vol 29, pp. 190-194 | es_ES |
| dc.subject | Acnistus arborescens | es_ES |
| dc.subject | Anti-inlammatory | es_ES |
| dc.subject | Sulfated withanolides | es_ES |
| dc.subject | Cytotoxicity | es_ES |
| dc.title | Bioassay-guided isolation of anti-inflammatory O-sulfated withanolides from Acnistus arborescens (Solanaceae) | es_ES |
| dc.type | artículo original |