Natural product based inhibitors of the thioredoxin-thioredoxin reductase system
| dc.creator | Wipf, Peter | |
| dc.creator | Lynch, Stephen M. | |
| dc.creator | Birmingham, Anne | |
| dc.creator | Tamayo Castillo, Giselle | |
| dc.creator | Jiménez Ardón, Allan Miguel | |
| dc.creator | Campos, Nefertiti | |
| dc.creator | Powis, Garth | |
| dc.date.accessioned | 2022-10-13T21:51:19Z | |
| dc.date.available | 2022-10-13T21:51:19Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | Spiroketal naphthodecalins are readily assembled by Barton's base mediated Ullmann binaphthyl ether coupling, Dakin reactions and hypervalent iodine spirocyclization. The core structures can be further diversified by enone addition and Stille coupling reactions. Nanomolar inhibitors for the Trx/TrxR redox control system were prepared by this approach and compared to series of natural product isolates. Cytotoxicity in MCF-7 cell assays ranged from an IC50 of 1.6 to >100 microM. | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química | es_ES |
| dc.description.sponsorship | National Institutes of Health/[U19CA-52995]/NIH/Estados Unidos | es_ES |
| dc.description.sponsorship | National Aeronautics and Space Administration/[NAG 13171]/NASA/Estados Unidos | es_ES |
| dc.identifier.citation | https://www.ncbi.nlm.nih.gov/nlmcatalog?term="Org+Biomol+Chem"%5BTitle+Abbreviation%5D | es_ES |
| dc.identifier.doi | 10.1039/b402431a | |
| dc.identifier.issn | 1477-0520 | |
| dc.identifier.issn | 1477-0539 | |
| dc.identifier.uri | https://hdl.handle.net/10669/87509 | |
| dc.language.iso | eng | es_ES |
| dc.rights | acceso embargado | |
| dc.source | Organic & Biomolecular Chemistry, vol.2 (11), pp.1651-1658. | es_ES |
| dc.subject | Thioredoxin | es_ES |
| dc.subject | Natural products | es_ES |
| dc.subject | Inhibitors | es_ES |
| dc.title | Natural product based inhibitors of the thioredoxin-thioredoxin reductase system | es_ES |
| dc.type | artículo original | es_ES |