Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia
| dc.creator | Herrera Vega, María | |
| dc.creator | Paiva, Owen K. | |
| dc.creator | Pagotto, Ana Helena | |
| dc.creator | Segura Ruiz, Álvaro | |
| dc.creator | Serrano, Solange M. T. | |
| dc.creator | Vargas Arroyo, Mariángela | |
| dc.creator | Villalta Arrieta, Mauren | |
| dc.creator | Jensen, Simon D. | |
| dc.creator | León Montero, Guillermo | |
| dc.creator | Williams, David J. | |
| dc.creator | Gutiérrez, José María | |
| dc.date.accessioned | 2017-06-14T20:54:40Z | |
| dc.date.available | 2017-06-14T20:54:40Z | |
| dc.date.issued | 2014-11-05 | |
| dc.description.abstract | Antivenoms manufactured by bioCSL Limited (Australia) and Instituto Clodomiro Picado (Costa Rica) against the venom of the taipan snakes (Oxyuranus scutellatus) from Australia and Papua New Guinea (PNG), respectively, were compared using antivenomics, an analytical approach that combines proteomics with immunoaffinity chromatography. Both antivenoms recognized all venom proteins present in venom from PNG O. scutellatus, although a pattern of partial recognition was observed for some components. In the case of the Australian O. scutellatus venom, both antivenoms immunorecognized the majority of the components, but the CSL antivenom showed a stronger pattern of immunoreactivity, which was revealed by the percentage of retained proteins in the immunoaffinity column. Antivenoms interacted with taipoxin in surface plasmon resonance. These observations on antivenomics agree with previous neutralization studies. | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
| dc.description.sponsorship | Fondos del Sistema Consejo Nacional de Rectores/[741-B2-652]/FEES-CONARE/Costa Rica | es_ES |
| dc.description.sponsorship | Universidad de Costa Rica/[741- B3-017]/UCR/Costa Rica | es_ES |
| dc.identifier.citation | http://www.ajtmh.org/content/91/5/887 | |
| dc.identifier.doi | 10.4269/ajtmh.14-0333 | |
| dc.identifier.issn | 1476-1645 | |
| dc.identifier.pmid | 25157124 | |
| dc.identifier.pmid | PMC4228881 | |
| dc.identifier.uri | https://hdl.handle.net/10669/30100 | |
| dc.language.iso | en_US | es_ES |
| dc.rights | acceso abierto | |
| dc.source | The American Journal of Tropical Medicine and Hygiene; Volumen 95, Número 5. 2015 | es_ES |
| dc.subject | Animals | es_ES |
| dc.subject | Antivenins | es_ES |
| dc.subject | Australia | es_ES |
| dc.subject | Costa Rica | es_ES |
| dc.subject | Elapid Venoms | es_ES |
| dc.subject | Elapidae | es_ES |
| dc.subject | Neutralization Tests | es_ES |
| dc.subject | Papua New Guinea | es_ES |
| dc.subject | Proteomics | es_ES |
| dc.subject | Surface Plasmon Resonance | es_ES |
| dc.subject | Snake venom | es_ES |
| dc.title | Antivenomic Characterization of Two Antivenoms Against the Venom of the Taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia | es_ES |
| dc.type | artículo original |