Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs
| dc.creator | Arias Echandi, María Laura | |
| dc.creator | Corrales Aguilar, Eugenia | |
| dc.creator | Poveda Rojas, Rebeca | |
| dc.creator | Cabezas Pizarro, Jorge A. | |
| dc.date.accessioned | 2023-03-16T19:24:20Z | |
| dc.date.available | 2023-03-16T19:24:20Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Natural product jacaranone, 1, and three analog derivatives were synthesized and their apoptotic and necrotic activity against four cancer cell lines was tested. One of these derivatives 7, was more active than the natural product, and exhibited an important necrotic effect against three of the cell lines tested (ovarian carcinoma, liver cancer and breast cancer cells). Derivative 6 was more active than the natural product, and showed a significant apoptotic ac- tivity against breast cancer and ovarian carcinoma cells. Some derivatives analyzed in this study showed promising anti-tumor results, nevertheless, further studies have to be done in order to determine their in vivo activity, their mechanism as well as their safety and stability | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET) | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Docencia::Salud::Facultad de Microbiología | es_ES |
| dc.description.procedence | UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Química | es_ES |
| dc.identifier.citation | https://www.scirp.org/journal/paperinformation.aspx?paperid=82845 | es_ES |
| dc.identifier.doi | 10.4236/ijoc.2018.81007 | |
| dc.identifier.issn | 2161-4695 | |
| dc.identifier.uri | https://hdl.handle.net/10669/88342 | |
| dc.language.iso | eng | es_ES |
| dc.rights | acceso abierto | |
| dc.source | International Journal of Organic Chemistry, vol.8(1), pp.115-124 | es_ES |
| dc.subject | MICROBIOLOGY | es_ES |
| dc.subject | CHEMISTRY | es_ES |
| dc.title | Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs | es_ES |
| dc.type | artículo original | es_ES |