Listar Investigación por autor "77dc6809-c7ef-4c96-8c4a-b66be0158dc5"
Mostrando ítems 1-4 de 4
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Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
Watanabe, Leandra; Shannon, John D.; Valente, Richard H.; Rucavado Romero, Alexandra; Alape Girón, Alberto; Kamiguti, Aura S.; Theakston, R. David G.; Fox, Jay W.; Gutiérrez, José María; Arni, Raghuvir K. (2003-10)BaP1 is a 22.7-kD P-I-type zinc-dependent metalloproteinase isolated from the venom of the snake Bothrops asper, a medically relevant species in Central America. This enzyme exerts multiple tissue-damaging activities, ... -
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy
Escalante Muñoz, Teresa; Rucavado Romero, Alexandra; Kamiguti, Aura S.; Theakston, R. David G.; Gutiérrez, José María (2004-02)The ability of the P-I metalloproteinase BaP1, isolated from the venom of the snake Bothrops asper, to induce systemic bleeding, thrombocytopenia and defibrinogenation was assessed in an experimental mouse model. Intravenous ... -
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis
Loría Masís, Gilbert David; Rucavado Romero, Alexandra; Kamiguti, Aura S.; Theakston, R. David G.; Fox, Jay W.; Alape Girón, Alberto; Gutiérrez, José María (2003-10)A prothrombin activator, named ‘basparin A,’ was isolated from the venom of the crotaline snake Bothrops asper, the species responsible for the majority of snakebite cases in Central America. It is an acidic (pI 5.4), 70 ... -
Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage
Rucavado Romero, Alexandra; Soto Morera, Mónica; Kamiguti, Aura S.; Theakston, R. David G.; Fox, Jay W.; Escalante Muñoz, Teresa; Gutiérrez, José María (2001-04)Thrombocytopenia occurs in a number of patients bitten by Bothrops asper, a species responsible for the majority of snakebites in Central America and southern Mexico. In this work we describe the isolation of a new ...