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Mostrando ítems 281-290 de 445
Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom
(2011-11)
Venoms of several Naja species found in Sub-Saharan Africa, and commonly known as "spitting cobras", induce a predominantly cytotoxic pattern of envenomings that may evolve into tissue necrosis and gangrene. Cytotoxic ...
Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa
(2010-02)
A preclinical assessment was performed on the neutralizing efficacy of a whole IgG polyspecific antivenom (EchiTAb-Plus-ICP®), designed for the treatment of snakebite envenomings in Nigeria. It was generated by immunizing ...
Calcium ion independent membrane leakage induced by phospholipase-like myotoxins
(1992-12)
The two snake venom myotoxins ammodytin L and myotoxin II, purified respectively from Vipera ammodytes ammodytes and Bothrops asper, have phospholipase-like structures but lack an Asp-49 in the active site and are without ...
Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: A biochemical and immunohistochemical study
(2016-11-15)
The hemorrhagic activity characteristic of viperid snake envenomations is due to the action of venom metalloproteinases (SVMPs) on the capillary vessel basement membrane (BM). This study compared the action of two SVMPs ...
Antivenomics: a proteomics tool for studying the immunoreactivity of antivenoms
(2015-03)
Envenoming following snakebite is largely a neglected threat to public health in tropical and subtropical regions of Africa, Asia, Latin America and Oceania addicting some of the world’s poorest rural communities. An ...
The recovery from the neuroparalysis caused by Micrurus nigrocinctus venom is accelerated by an agonist of the CXCR4 receptor
(2022)
Snake envenoming is a major but neglected human disease in tropical and subtropical regions. Among venomous snakes in the Americas, coral snakes of the genus Micrurus are particularly dangerous because they cause a peripheral ...
DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants.
(1991)
DNase activity of Costa Rican crotaline snake venoms from the genera Bothrops, Crotalus and Lachesis was quantified by an enzymodiffusion method on agarose/DNA gels containing ethidium bromide. The reaction is detected as ...
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms
(2000-09)
Changes in serum levels of several cytokines and nitric oxide were studied in BALB/c mice injected intraperitoneally with one median lethal dose (LD(50)) of the venoms of Bothrops asper and Bothrops jararaca, two of the ...
Envenenamientos por mordeduras de serpientes en América Latina y el Caribe: Una visión integral de carácter regional
Snakebite poisoning in Latin America and the Caribbean: An integral view from a regional perspective
(2011-01)
Se analiza la situación de los envenenamientos por
mordeduras de serpiente en América Latina y el Caribe, los
cuales representan un importante problema de Salud Pública
en la región. Esta patología afecta, fundamentalmente, ...
Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper)
(1993-08)
Two myotoxins isolated from B. asper (myotoxin II) and B. nummifer (myotoxin I) snake venoms have been crystallized and their diffraction properties are described. These myotoxins are phospholipase A2 variants which lack ...