Show simple item record

dc.creatorOussaief, Lassades_ES
dc.creatorHippocrate, Auréliees_ES
dc.creatorClybouw, Cyriles_ES
dc.creatorRampanou, Aurorees_ES
dc.creatorRamírez Mayorga, Vanessaes_ES
dc.creatorClaude, Desgrangeses_ES
dc.creatorVasquez, Aimees_ES
dc.creatorKhelifa, Ridhaes_ES
dc.creatorJoab, Irènees_ES
dc.date.accessioned2015-07-08T19:59:16Zes_ES
dc.date.available2015-07-08T19:59:16Zes_ES
dc.date.issued2009-02-28es_ES
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0042682209001202es_ES
dc.identifier.issn0042-6822es_ES
dc.identifier.urihttp://hdl.handle.net/10669/15067es_ES
dc.descriptionArtículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2009es_ES
dc.description.abstractThe Epstein–Barr virus (EBV) generally latently infects its target cells with expression of genes conferring resistance to apoptosis. However, the modulation of apoptotic signals during lytic cycle remains poorly understood. We show here that resulting from viral reactivation in the EBV-positive Mutu-I and Akata Burkitt's lymphoma cell lines, a two steps proteasome-dependent downregulation of expression of the proapoptotic protein BimEL occurs. The first drop might be EBV-independent, is ERK 1/2 dependent, and BimEL is phosphorylated on Ser69. A second dramatic drop of the BimEL level observed during the lytic cycle is dependent of EBV-late-gene expression, ERK 1/2 independent, and no further phosphorylation of BimEL on Ser69 occurred. These results demonstrate for the first time, that the lytic cycle contributes to downregulation of BimEL and then could add to protection against apoptosis.es_ES
dc.description.sponsorshipUniversité Parises_ES
dc.description.sponsorshipUniversidad de Costa Rica. Instituto de Investigaciones en Saludes_ES
dc.language.isoen_USes_ES
dc.publisherVirology 387 (2009) (1) p.41.49es_ES
dc.sourceVirology 387: 41-49es_ES
dc.subjectReactivationes_ES
dc.subjectEBVes_ES
dc.subjectBurkitt's lymphomaes_ES
dc.subjectBimELes_ES
dc.titleActivation of the lytic program of the Epstein–Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.virol.2009.02.009es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record