Listar Microbiología por autor "76f87e9a-e8dd-481b-a881-1546ff7bb72b"
Mostrando ítems 1-8 de 8
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Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis
Laustsen, Andreas Hougaard; Gutiérrez, José María; Rasmussen, Arne R.; Engmark, Mikael Gerling; Gravlund, Peter; Sanders, Kate L.; Lohse, Brian; Lomonte, Bruno (2015-12-01)Four specimens of the olive sea snake, Aipysurus laevis, were collected off the coast of Western Australia, and the venom proteome was characterized and quantitatively estimated by RP-HPLC, SDS-PAGE, and MALDI-TOF-TOF ... -
From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy
Laustsen, Andreas Hougaard; Engmark, Mikael Gerling; Milbo, Christina; Johannesen, Jonás; Lomonte, Bruno; Gutiérrez, José María; Lohse, Brian (2016)The snake is the symbol of medicine due to its association with Asclepius, the Greek God of medicine, and so with good reasons. More than 725 species of venomous snakes have toxins specifically evolved to exert potent ... -
In vivo neutralization of Myotoxin II, a phospholipase A2 homolog from Bothrops asper venom, using peptides discovered via phage display technology
Laustsen, Andreas Hougaard; Gless, Bengt H.; Jenkins, Timothy P.; Meyhoff Madsen, Maria; Bjärtun, Johanna; Munk, Andreas S.; Oscoz, Saioa; Fernández Ulate, Julián; Gutiérrez, José María; Lomonte, Bruno; Lohse, Brian (2022)Many snake venom toxins cause local tissue damage in prey and victims, which constitutes an important pathology that is challenging to treat with existing antivenoms. One of the notorious toxins that causes such effects ... -
Myotoxin-neutralizing peptides
Lohse, Brian; Laustsen, Andreas Hougaard; Fernández Ulate, Julián; Cob, Saioa; Lomonte, Bruno; Gutiérrez, José María (2018-03-27)The present invention relates to polypeptides having myotoxin-neutralizing properties and their use for treatment of envenomation. The present invention further relates to methods for neutralizing a venom using the polypeptide ... -
Pitfalls to avoid when using phage display for snake toxins
Laustsen, Andreas Hougaard; Lauridsen, Line Præst; Lomonte, Bruno; Andersen, Mikael Rørdam; Lohse, Brian (2017-02)Antivenoms against bites and stings from snakes, spiders, and scorpions are associated with immunological side effects and high cost of production, since these therapies are still derived from the serum of hyper-immunized ... -
Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score
Laustsen, Andreas Hougaard; Lohse, Brian; Lomonte, Bruno; Engmark, Mikael Gerling; Gutiérrez, José María (2015-09-15)For more than 100 years, antivenoms have been produced by traditional methods of immunization of large mammals with mixtures of snake venoms (World Health Organization, 2010 and Gutiérrez et al., 2011). With the introduction ... -
Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins
Laustsen, Andreas Hougaard; Gutiérrez, José María; Lohse, Brian; Rasmussen, Arne R.; Fernández Ulate, Julián; Milbo, Christina; Lomonte, Bruno (2015-06)The venom proteome of the monocled cobra, Naja kaouthia, from Thailand, was characterized by RPHPLC, SDS-PAGE, and MALDI-TOF-TOF analyses, yielding 38 different proteins that were either identified or assigned to families. ... -
Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: identification of key toxin targets for antivenom development.
Laustsen, Andreas Hougaard; Lomonte, Bruno; Lohse, Brian; Fernández Ulate, Julián; Gutiérrez, José María (2015-04-24)The venom proteome of the black mamba, Dendroaspis polylepis, from Eastern Africa, was, for the first time, characterized. Forty- different proteins and one nucleoside were identified or assigned to protein families. The ...