• Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide 

      Barquero Calvo, Elías; Mora Cartín, Ricardo; Arce Gorvel, Vilma; de Diego, Juana L.; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Buret, Andre G.; Gorvel, Jean Pierre; Moreno Robles, Edgardo (2015-05-06)
      Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ...
    • Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains 

      Suárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Castillo Zeledón, Amanda; Jiménez Rojas, César; Martin Roop II, Roy; Comerci, Diego J.; Barquero Calvo, Elías; Chacón Díaz, Carlos; Caswell, Clayton C.; Baker, Kate S.; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Letesson, Jean J.; De Bolle, Xavier; Guzmán Verri, Caterina (2016-09-29)
      Brucellosis is a bacterial infectious disease affecting a wide range of mammals and a neglected zoonosis caused by species of the genetically homogenous genus Brucella. As in most studies on bacterial diseases, research ...
    • Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts 

      Chacón Díaz, Carlos; Altamirano Silva, Pamela; González Espinoza, Gabriela; Medina, María Concepción; Alfaro Alarcón, Alejandro; Bouza Mora, Laura; Jiménez Rojas, César; Wong Araya, Melissa; Barquero Calvo, Elías; Rojas Campos, Norman; Guzmán Verri, Caterina; Moreno Robles, Edgardo; Chaves Olarte, Esteban (2015-11-10)
      Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...
    • Brucella Genetic Variability in Wildlife Marine Mammals Populations Relates to Host Preference and Ocean Distribution 

      Suárez Esquivel, Marcela; Baker, Kate S.; Ruiz Villalobos, Nazareth; Hernández Mora, Gabriela; Barquero Calvo, Elías; Castillo Zeledón, Amanda; Jiménez Rojas, César; Chacón Díaz, Carlos; Cloeckaert, Axel; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Guzmán Verri, Caterina; González Barrientos, Rocío (2017)
      Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ...
    • Brucella neotomae Infection in Humans, Costa Rica 

      Suárez Esquivel, Marcela; Ruiz Villalobos, Nazareth; Jiménez Rojas, César; Barquero Calvo, Elías; Chacón Díaz, Carlos; Víquez Ruiz, Eunice; Rojas Campos, Norman; Baker, Kate S.; Oviedo Sánchez, Gerardo; Amuy, Ernesto; Chaves Olarte, Esteban; Thomson, Nicholas R.; Moreno Robles, Edgardo; Guzmán Verri, Caterina (2017-06)
      Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...
    • Brucellosis caused by the wood rat pathogen Brucella neotomae: two case reports 

      Villalobos Vindas, Juan M.; Amuy, Ernesto; Barquero Calvo, Elías; Rojas Campos, Norman; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Moreno Robles, Edgardo (2017-12-19)
      Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified two ...
    • Brucellosis in mammals of Costa Rica: An epidemiological survey 

      Hernández Mora, Gabriela; Bonilla Montoya, Roberto; Barrantes Granados, Osvaldo; Esquivel Suárez, Andrea; Montero Caballero, Danilo; González Barrientos, Rocío; Fallas Monge, Zeanne; Palacios Alfaro, José David; Baldi Salas, Mario; Campos Chacón, Elena; Chanto Chacón, Grettel; Barquero Calvo, Elías; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Romero Zúñiga, Juan José; Moreno Robles, Edgardo (2017-08-09)
      Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in the ...
    • Depletion of complement enhances the clearance of Brucella abortus in mice 

      González Espinoza, Gabriela; Barquero Calvo, Elías; Lizano González, Esteban; Alfaro Alarcón, Alejandro; Arias Gómez, Berny; Chaves Olarte, Esteban; Lomonte, Bruno; Moreno Robles, Edgardo; Chacón Díaz, Carlos (2018)
      Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. ...
    • Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease 

      Hernández Mora, Gabriela; Ruiz Villalobos, Nazareth; Bonilla Montoya, Roberto; Romero Zúñiga, Juan José; Jiménez Arias, Julio; González Barrientos, Rocío; Barquero Calvo, Elías; Chacón Díaz, Carlos; Rojas Campos, Norman; Chaves Olarte, Esteban; Guzmán Verri, Caterina; Moreno Robles, Edgardo (2017-08)
      Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR were ...
    • High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica 

      Rojas Núñez, Irene; Barquero Calvo, Elías; van Balen, Joany C.; Rojas Campos, Norman; Muñoz Vargas, Lohendy; Hoet, Armando E. (2017-08-17)
      Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen associated with severe infections in companion animals present in the community, and it is diagnosed in animals admitted to veterinary hospitals. However, ...
    • N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils 

      Mora Cartín, Ricardo; Chacón Díaz, Carlos; Gutiérrez Jiménez, Cristina; Gurdián Murillo, Stephany; Lomonte, Bruno; Chaves Olarte, Esteban; Barquero Calvo, Elías; Moreno Robles, Edgardo (2016-06)
      Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...
    • Neutrophils as Trojan Horse Vehicles for Brucella abortus Macrophage Infection 

      Gutiérrez Jiménez, Cristina; Mora Cartín, Ricardo; Altamirano Silva, Pamela; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Moreno Robles, Edgardo; Barquero Calvo, Elías (2019-05-07)
      Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B. abortus-infected ...
    • Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals 

      Hernández Mora, Gabriela; Chacón Díaz, Carlos; Moreira Soto, Andrés; Barrantes Granados, Osvaldo; Suárez Esquivel, Marcela; Víquez Ruiz, Eunice; Barquero Calvo, Elías; Ruiz Villalobos, Nazareth; Hidalgo Montealegre, Daniela; González Barrientos, Rocío; Demeter, Elena A.; Estrella Morales, Josimar; Zúñiga Pereira, Ana Mariel; Quesada Gómez, Carlos; Chaves Olarte, Esteban; Lomonte, Bruno; Guzmán Verri, Caterina; Drexler, Jan Felix; Moreno Robles, Edgardo (2023)
      Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical and tropical areas of the American continent. Here, we report ...