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Two-dimensional gel electrophoresis (2D-GE) image analysis based on CellProfiler: Pseudomonas aeruginosa AG1 as model
(2020)
Two-dimensional gel electrophoresis (2D-GE) is an indispensable technique for the study of proteomes of biological systems,
providing an assessment of changes in protein abundance under various experimental conditions. ...
Gene Expression Dynamics Induced by Ciprofloxacin and Loss of LexA Function in Pseudomonas aeruginosa PAO1 Using Data Mining and Network Analysis
(2018)
Pseudomonas aeruginosa is an opportunistic
pathogen that causes a variety of infections in humans and
frequently develops mechanisms of resistance to antibiotics, which
makes its treatment difficult. In this study we ...
Molecular Determinants of Antibiotic Resistance in the Costa Rican Pseudomonas aeruginosa AG1 by a Multi-omics Approach: A Review of 10 Years of Study
(2021)
Pseudomonas aeruginosa AG1 (PaeAG1) is a Costa Rican strain that was isolated in 2010 in a major Hospital. This strain
has resistance to multiple antibiotics such as β-lactams (including carbapenems), aminoglycosides, and ...
SARS-CoV-2 genomic surveillance in Costa Rica: Evidence of a divergent population and an increased detection of a spike T1117I mutation
(2021)
Genome sequencing is a key strategy in the surveillance of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Latin America is the hardest-hit region of the world, accumulating almost 20% of COVID-19 cases ...
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
Clinical profiles at the time of diagnosis of COVID-19 in Costa Rica during the pre-vaccination period using a machine learning approach
(2021)
Background: The clinical manifestations of COVID-19 disease, caused by the SARS-CoV-2
virus, define a large spectrum of symptoms that are mainly dependent on the human host
conditions. In Costa Rica, almost 319 000 cases ...
Avances de la bioinformática en Costa Rica: Vista retrospectiva y perspectivas
Bioinformatics advances in Costa Rica: Retrospective view and perspectives
(2021-11-09)
Introducción: La disciplina científica de la bioinformática tiene el potencial de generar aplicaciones innovadoras para las sociedades humanas. Costa Rica, pequeña en tamaño y población en comparación con otros países de ...
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
(2018)
Cancer is a group of heterogeneous and complex
diseases, with limited therapeutic options due to the recurrent
emergence of drug resistance. Sphingolipids are bioactive
molecules that participate in signaling of cell ...
Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease
(2022-03-15)
Chronic gastrointestinal (GI) diseases are the most common diseases in captive common marmosets. To understand the role of the microbiome in GI diseases, we characterized the gut microbiome of 91 healthy marmosets (303 ...
Set-theory based benchmarking of three different variant callers for targeted sequencing
(2021)
Background: Next generation sequencing (NGS) technologies have improved the
study of hereditary diseases. Since the evaluation of bioinformatics pipelines is not
straightforward, NGS demands efective strategies to analyze ...