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dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.creatorRojas Céspedes, Gustavo
dc.creatorLomonte, Bruno
dc.creatorRucavado Romero, Alexandra
dc.creatorChaves Mora, Fernando
dc.date.accessioned2017-01-18T21:53:04Z
dc.date.available2017-01-18T21:53:04Z
dc.date.issued1998-11
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010198001457es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29442
dc.description.abstractLocal tissue damage represents a serious consequence of Bothrops asper envenomations. It encompasses a complex series of alterations, including myonecrosis, dermonecrosis, hemorrhage and edema. Due to its rapid development it is difficult to neutralize by antivenoms, especially if there is a delay in serotherapy. Experimental studies with this venom and the polyvalent (Crotalinae) antivenom produced in Costa Rica indicate that antivenom is effective in neutralizing these toxic activities when incubated with the venom prior to injection. However, if venom and antivenom are injected independently in mice, neutralization of these effects is only partial. Moreover, neutralization is not complete even if homologous or heterologous antibodies are present in the circulation before venom is injected. Despite differences in their pharmacokinetic profiles, equine whole IgG and F(ab')2 antivenoms show similar efficacy in the neutralization of edema, hemorrhage and myonecrosis induced by B. asper venom, suggesting that the use of antivenoms made of antibody fragments may not improve neutralization of these effects. This is due, at least in part, to the fact that microvessel disruption by venom components favors a similar antibody concentration in the affected tissues. Recent advances in the development of neutralizing substances of rapid diffusion, that could be injected locally in the field, may contribute to the neutralization of metalloproteinases and phospholipases A2. In addition, the rapid administration of antivenoms with high antibody titers against locally-acting toxins is very important in the treatment of these effects.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-89-057]/UCR/Costa Ricaes_ES
dc.description.sponsorshipInternational Foundation for Science/[F/0883-4]/IFS/Sueciaes_ES
dc.description.sponsorshipInternational Foundation for Science/[F/1388-3F]/IFS/Sueciaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 36, Número 11, 1998es_ES
dc.subjectAnimalses_ES
dc.subjectAntiveninses_ES
dc.subjectBothropses_ES
dc.subjectCrotalid Venomses_ES
dc.subjectEdemaes_ES
dc.subjectForecastinges_ES
dc.subjectImmunoglobulin Ees_ES
dc.subjectImmunoglobulin Fab Fragmentses_ES
dc.subjectImmunotherapyes_ES
dc.subjectMicees_ES
dc.subjectSnake venomes_ES
dc.titleNeutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venomes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/S0041-0101(98)00145-7
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-89-057


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